HYOSCYAMINE SULFATE injection, solution

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

HYOSCYAMINE SULFATE (UNII: F2R8V82B84) (HYOSCYAMINE - UNII:PX44XO846X)

から入手可能:

BPI Labs LLC

投与経路:

SUBCUTANEOUS

処方タイプ:

PRESCRIPTION DRUG

適応症:

Hyoscyamine sulfate Injection, USP is effective as adjunctive therapy in the treatment of peptic ulcer. In acute episodes, Hyoscyamine sulfate Injection, USP can be used to control gastric secretion, visceral spasm and hypermotility in spastic colitis, spastic bladder, cystitis, pylorospasm, and associated abdominal cramps. For use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and functional gastrointestinal disorders. Also as adjunctive therapy in the treatment of neurogenic bladder and neurogenic bowel disturbances (including the splenic flexure syndrome and neurogenic colon). Parenterally administered Hyoscyamine sulfate Injection, USP is also effective in reducing gastrointestinal motility to facilitate diagnostic procedures such as endoscopy or hypotonic duodenography. Hyoscyamine sulfate Injection, USP may be used to reduce pain and hypersecretion in pancreatitis, in certain cases of partial heart block associated with vagal activity,

製品概要:

Hyoscyamine sulfate injection USP (Hyoscyamine sulfate injection USP, 0.5 mg/mL), is available in 1 mL vials. 1 mL vials – Box of 5 NDC 54288-111-05 Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Also available as: Product    Dosage Strength     Package Size      NDC   Hyoscyamine sulfate injection, USP         0.5 mg/mL                          5 Vials (1 mL Each)           54288-111-05

認証ステータス:

unapproved drug other

製品の特徴

HYOSCYAMINE SULFATE- HYOSCYAMINE SULFATE INJECTION, SOLUTION
BPI LABS LLC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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DESCRIPTION
Hyoscyamine sulfate injection, USP is a sterile solution containing
0.5 mg hyoscyamine
sulfate per mL in water for injection.
Hyoscyamine sulfate Injection, USP is one of the principal
anticholinergic/antispasmodic
components of belladonna alkaloids. The empirical formula is (C
H
NO
)
•H
SO
•2H
0 and the molecular weight is 712.85. Chemically, it is benzeneacetic
acid, α-
(hydroxymethyl)-,8-methyl-8-azabicyclo [3.2.1.] oct-3-yl ester,
[3(S)-endo]-, sulfate
(2:1), dihydrate with the following structure:
The 1 mL vials contain as inactive ingredients: water for injection,
pH is adjusted with
hydrochloric acid when necessary.
CLINICAL PHARMACOLOGY
Hyoscyamine sulfate Injection, USP inhibits specifically the actions
of acetylcholine on
structures innervated by postganglionic cholinergic nerves and on
smooth muscles that
respond to acetylcholine but lack cholinergic innervation. These
peripheral cholinergic
receptors are present in the autonomic effector cells of the smooth
muscle, cardiac
muscle, the sinoatrial node, the atrioventricular node, and the
exocrine glands. It is
completely devoid of any action in the autonomic ganglia. Hyoscyamine
sulfate Injection,
USP inhibits gastrointestinal propulsive motility and decreases
gastric acid
secretion. Hyoscyamine sulfate Injection, USP also controls excessive
pharyngeal,
tracheal and bronchial secretions.
Hyoscyamine sulfate Injection, USP disappears rapidly from the blood
and is distributed
throughout the entire body. The half-life of Hyoscyamine sulfate
Injection, USP is 31/2
hours. Hyoscyamine sulfate Injection, USP is partly hydrolyzed to
tropic acid and tropine
but the majority of the drug is excreted in the urine unchanged within
the first 12 hours.
Only traces of this drug are fo