FLUNIXIJECT- flunixin meglumine injection, solution

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

FLUNIXIN MEGLUMINE (UNII: 8Y3JK0JW3U) (FLUNIXIN - UNII:356IB1O400)

から入手可能:

Henry Schein Animal Health

INN（国際名）:

FLUNIXIN MEGLUMINE

構図:

FLUNIXIN MEGLUMINE 50 mg in 1 mL

投与経路:

INTRAMUSCULAR

処方タイプ:

PRESCRIPTION

適応症:

INDICATIONS Horse: FlunixiJect™ Injectable Solution is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorders in the horse. It is also recommended for the alleviation of visceral pain associated with colic in the horse. Cattle: FlunixiJect™ Injectable Solution is indicated for the control of pyrexia associated with bovine respiratory disease, endotoxemia and acute bovine mastitis. FlunixiJect™ Injectable Solution is also indicated for the control of inflammation in endotoxemia. CONTRAINDICATIONS Horse: There are no known contraindications to this drug when used as directed. Intra-arterial injection should be avoided. Horses inadvertently injected intra-arterially can show adverse reactions. Signs can be ataxia, incoordination, hyperventilation, hysteria, and muscle weakness. Signs are transient and disappear without antidotal medication within a few minutes. Do not use in horses showing hypersensitivity to flunixin meglumine. Cattle: NSAIDS inhibit production of

製品概要:

HOW SUPPLIED FlunixiJect™ Injectable Solution, 50 mg/mL, is available in 100 mL and 250 mL multi-dose vials.

認証ステータス:

Abbreviated New Animal Drug Application

製品の特徴

FLUNIXIJECT- FLUNIXIN MEGLUMINE INJECTION, SOLUTION
HENRY SCHEIN ANIMAL HEALTH
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FLUNIXIJECT™
(flunixin meglumine) Injectable Solution
50 MG/ML VETERINARY
For Intravenous or Intramuscular Use in Horses and for Intravenous Use
in Beef and Dairy Cattle. Not
for Use in Dry Dairy Cows and Veal Calves.
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Each milliliter of FlunixiJect™ Injectable Solution contains
flunixin meglumine equivalent to 50 mg
flunixin, 0.1 mg edetate disodium, 2.2 mg sodium formaldehyde
sulfoxylate, 4.0 mg diethanolamine,
207.2 mg propylene glycol, 5.0 mg phenol as preservative, hydrochloric
acid, water for injection q.s.
PHARMACOLOGY
Flunixin meglumine is a potent, non-narcotic, nonsteroidal, analgesic
agent with anti-inflammatory and
antipyretic activity. It is significantly more potent than
pentazocine, meperidine, and codeine as an
analgesic in the rat yeast paw test.
HORSE: Flunixin is four times as potent on a mg-per-mg basis as
phenylbutazone as measured by the
reduction in lameness and swelling in the horse. Plasma half-life in
horse serum is 1.6 hours following
a single dose of 1.1 mg/kg. Measurable amounts are detectable in horse
plasma at 8 hours postinjection.
CATTLE: Flunixin meglumine is a weak acid (pKa=5.82)1 which exhibits a
high degree of plasma protein
binding (approximately 99%).2 However, free (unbound) drug appears to
readily partition into body
tissues (Vss predictions range from 297 to 782 mL/kg.2-5 Total body
water is approximately equal to
570 mL/kg).6 In cattle, elimination occurs primarily through biliary
excretion.7 This may, at least in part,
explain the presence of multiple peaks in the blood concentration/time
profile following IV
administration.2
In healthy cattle, total body clearance has been reported to range
from 90-151 mL/kg/hr.2-5 These
studies also report a large discrepancy between the volume of
distribution at steady state (Vss) and the
volume of distribution associated with the termin