DIGOX digoxin tablet

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

DIGOXIN (UNII: 73K4184T59) (DIGOXIN - UNII:73K4184T59)

から入手可能:

McKesson Contract Packaging

INN（国際名）:

DIGOXIN

構図:

DIGOXIN 125 ug

処方タイプ:

PRESCRIPTION DRUG

認証ステータス:

Abbreviated New Drug Application

製品の特徴

DIGOX- DIGOXIN TABLET
MCKESSON CONTRACT PACKAGING
----------
DIGOX
DESCRIPTION
Digoxin is one of the cardiac (or digitalis) glycosides, a closely
related group of drugs having in
common specific effects on the myocardium. These drugs are found in a
number of plants. Digoxin is
extracted from the leaves of _Digitalis lanata_. The term
“digitalis” is used to designate the whole group
of glycosides. The glycosides are composed of two portions: a sugar
and a cardenolide (hence
“glycosides”).
Digoxin is described chemically as
(3β,5β,12β)-3-[(_0_-2,6-dideoxy-β-_D-ribo_-hexopyranosyl-(1→4)-_0_-
2,6-dideoxy-β-_D-ribo_-hexopyranosyl-(1→4)-2,6-dideoxy-β-_D-ribo_-hexopyranosyl)oxy]-12,14-
dihydroxy-card-20(22)-enolide. Its molecular formula is C
H O , its molecular weight is
780.95, and its structural formula is:
Digoxin exists as odorless white crystals that melt with decomposition
above 230°C. The drug is
practically insoluble in water and in ether; slightly soluble in
diluted (50%) alcohol and in chloroform;
and freely soluble in pyridine.
Digoxin is supplied as 125 mcg (0.125 mg) or 250 mcg (0.25 mg) tablets
for oral administration. Each
tablet contains the labeled amount of digoxin USP and the following
inactive ingredients: 0.250 mg -
colloidal silicon dioxide, croscarmellose sodium, lactose anhydrous,
magnesium stearate,
microcrystalline cellulose, stearic acid.
0.125 mg - colloidal silicon dioxide, croscarmellose sodium, D&C
yellow aluminum lake #10, lactose
anhydrous, magnesium stearate, microcrystalline cellulose, stearic
acid.
CLINICAL PHARMACOLOGY
41
64
14
MECHANISM OF ACTION
Digoxin inhibits sodium-potassium ATPase, an enzyme that regulates the
quantity of sodium and
potassium inside cells. Inhibition of the enzyme leads to an increase
in the intracellular concentration of
sodium and thus (by stimulation of sodium-calcium exchange) an
increase in the intracellular
concentration of calcium. The beneficial effects of digoxin result
from direct actions on cardiac
muscle, as well as indirect act