国: アメリカ合衆国
言語: 英語
ソース: NLM (National Library of Medicine)
DIETHYLPROPION HYDROCHLORIDE (UNII: 19V2PL39NG) (DIETHYLPROPION - UNII:Q94YYU22B8)
Preferred Pharmaceuticals, Inc.
ORAL
PRESCRIPTION DRUG
Diethylpropion hydrochloride is indicated in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m2 or higher and who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone. Below is a chart of BMI based on various heights and weights. BMI is calculated by taking the patient’s weight, in kilograms (kg), divided by the patient’s height, in meters (m), squared. Metric conversions are as follows: pounds divided by 2.2 = kg; inches x 0.0254 = meters. 140 27 25 23 21 19 18 150 29 27 24 22 20 19 160 31 28 26 24 22 20 170 33 30 28 25 23 21 180 35 32 29 27 25 23 190 37 34 31 28 26 24 200 39 36 32 30 27 25 210 41 37 34 31 29 26 220 43 39 36 33 30 28 230 45 41 37 34 31 29 240 47 43 39 36 33 30 250 49 44 40 37 34 31 The usefulness of agents of this class (see CLINI
75 mg controlled-release tablets in bottles of; Each white, capsule-shaped tablet is debossed Watson 782 . Bottle of 14 - 68788-0686-1 Bottle of 20 - 68788-0686-2 Bottle of 30 - 68788-0686-3 Bottle of 60 - 68788-0686-6 Keep tightly closed. Store at room temperature, below 30°C (86°F). Rx only Distributed By: Actavis Pharma, Inc. Parsippany, NJ 07054 Manufactured By: Patheon Pharmaceuticals Inc. Cincinnati, OH 45237 USA Content Updated: March 2014 70025263 Repackaged by Preferred Pharmaceuticals, Inc.
New Drug Application
DIETHYLPROPION HCL CONTROLLED-RELEASE- DIETHYLPROPION HYDROCHLORIDE TABLET PREFERRED PHARMACEUTICALS, INC. ---------- 70025263 DIETHYLPROPION HCL USP C-IV IMMEDIATE-RELEASE 25 MG TABLETS DIETHYLPROPION HCL USP C-IV CONTROLLED-RELEASE 75 MG TABLETS RX ONLY REV. MARCH 2014 DESCRIPTION Diethylpropion hydrochloride is available for oral administration in immediate-release tablets containing 25 mg diethylpropion hydrochloride and in controlled-release tablets containing 75 mg diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: cornstarch, lactose, magnesium stearate, pregelatinized cornstarch, talc, and tartaric acid. The inactive ingredients in each controlled-release tablet are: carbomer 934P, mannitol, povidone, tartaric acid, zinc stearate. Diethylpropion hydrochloride is a sympathomimetic agent. The chemical name for diethylpropion hydrochloride is 1-phenyl-2-diethylamino-1-propanone hydrochloride. Its chemical structure is: The diethylpropion hydrochloride 75 mg formulation is dispersed in a hydrophilic matrix. On exposure to water, the diethylpropion hydrochloride is released at a relatively uniform rate as a result of slow hydration of the matrix. The result is controlled release of the anorectic agent. CLINICAL PHARMACOLOGY Diethylpropion hydrochloride is a sympathomimetic amine with some pharmacologic activity similar to that of the prototype drugs of this class used in obesity, the amphetamines. Actions include some central nervous system stimulation and elevation of blood pressure. Tolerance has been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known as "anorectics" or "anorexigenics." It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression. For example, other central nervous system actions or metabolic effects may be involved. Adult obese subjects instructed in dietary management and treated with "anor 完全なドキュメントを読む