DEXAMETHASONE- dexamethasone injection, solution

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

Dexamethasone (UNII: 7S5I7G3JQL) (Dexamethasone - UNII:7S5I7G3JQL)

から入手可能:

Agri Laboratories Ltd.

投与経路:

INTRAMUSCULAR

処方タイプ:

PRESCRIPTION

適応症:

INDICATIONS:   Dexamethasone Injection is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine.  As supportive therapy, Dexamethasone Injection may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids.  Dexamethasone Injection may be used intravenously as supportive therapy when an immediate hormonal response is required. Bovine Ketosis:   Dexamethasone Injection is offered for the treatment of primary ketosis.  The gluconeogenic effects of Dexamethasone Injection, when administered intramuscularly, are generally noted within the first 6 to 12 hours.  When Dexamethasone Injection is used intravenously, the effects may be noted sooner.  Blood sugar levels rise to normal levels rapidly and generally rise to above normal levels within 12 to 24 hours.  Acetone bodies are reduced to normal concentrations usually within 24 hours.  The physical attitude of anim

製品概要:

HOW SUPPLIED:  Dexamethasone Injection, 2 mg per mL, 100 mL multiple dose vial.

認証ステータス:

Abbreviated New Animal Drug Application

製品の特徴

DEXAMETHASONE- DEXAMETHASONE INJECTION, SOLUTION
AGRI LABORATORIES LTD.
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CAUTION: Federal law restricts this drug to use by or on the order of
a licensed veterinarian.
DESCRIPTION: Dexamethasone Solution is a synthetic analogue of
prednisolone, having similar but
more potent anti-inflammatory therapeutic action and diversified
hormonal and metabolic effects.
Modification of the basic corticoid structure as achieved in
Dexamethasone Injection offers enhanced
anti-inflammatory effect compared to older corticosteroids. The dosage
of Dexamethasone
Injection required is markedly lower than that of prednisone and
prednisolone. Dexamethasone Injection
is not species-specific; however, the veterinarian should read the
sections on INDICATIONS,
DOSAGE, SIDE EFFECTS, CONTRAINDICATIONS, PRECAUTIONS, and WARNINGS
before this
drug is used.
Dexamethasone Injection is intended for intravenous or intramuscular
administration. Each mL contains
2 mg dexamethasone, 500 mg polyethylene glycol 400, 9 mg benzyl
alcohol, 1.8 mg methylparaben and
0.2 mg propylparaben as preservatives, 4.75% alcohol, HCl to adjust pH
to approximately 4.9, water
for injection q.s.
EXPERIMENTAL STUDIES: Experimental animal studies on dexamethasone
have revealed it
possesses greater anti-inflammatory activity than many steroids.
Veterinary clinical evidence indicates
dexamethasone has approximately 20 times the anti-inflammatory
activity of prednisolone and 70 to 80
times that of hydrocortisone. Thymus involution studies show
dexamethasone possesses 25 times the
activity of prenisolone. In reference to mineralcorticoid activity,
dexamethasone does not cause
significant sodium or water retention. Metabolic balance studies show
that animals on controlled and
limited protein intake will exhibit nitrogen losses on exceedingly
high dosages.
INDICATIONS: Dexamethasone Injection is indicated for the treatment of
primary bovine ketosis and
as an anti-inflammatory agent in the bovine and equine. As supportive
therapy, Dexamethasone Injection
may be used in