DEMECLOCYCLINE HYDROCHLORIDE tablet

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

DEMECLOCYCLINE HYDROCHLORIDE (UNII: 29O079NTYT) (DEMECLOCYCLINE - UNII:5R5W9ICI6O)

から入手可能:

Carilion Materials Management

INN（国際名）:

DEMECLOCYCLINE HYDROCHLORIDE

構図:

DEMECLOCYCLINE HYDROCHLORIDE 150 mg

投与経路:

ORAL

処方タイプ:

PRESCRIPTION DRUG

適応症:

To reduce the development of drug-resistant bacteria and maintain the effectiveness of demeclocycline hydrochloride tablets and other antibacterial drugs, demeclocycline hydrochloride tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.  When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.  In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy. Demeclocycline hydrochloride is indicated in the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions below: Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by rickettsiae; Respiratory tract infections caused by ; Lymphogranuloma venereum due to ; Psittacosis (Ornithosis) due to ; Trachoma due to , although the infectious

製品概要:

NDC:68151-0155-1 in a PACKAGE of 1 TABLETS

認証ステータス:

Abbreviated New Drug Application

製品の特徴

Carilion Materials Management
DEMECLOCYCLINE HYDROCHLORIDE - DEMECLOCYCLINE HYDROCHLORIDE TABLET
CARILION MATERIALS MANAGEMENT
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DEMECLOCYCLINE HYDROCHLORIDE TABLETS, USP
(FILM COATED)
FULL PRESCRIBING INFORMATION
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of demeclocycline
hydrochloride tablets and other antibacterial drugs, demeclocycline
hydrochloride tablets should be
used only to treat or prevent infections that are proven or strongly
suspected to be caused by bacteria.
DESCRIPTION
Demeclocycline hydrochloride is an antibiotic isolated from a mutant
strain of . Chemically it is 7-
Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,
12a-pentahydroxy-1,11-dioxo-2-
naphthacenecarboxamide monohydrochloride. Its structural formula is:
_Streptomyces aureofaciens_
Demeclocycline hydrochloride film coated tablets for oral
administration contain 150 mg or 300 mg of
demeclocycline hydrochloride and the following inactive ingredients:
alginic acid, corn starch,
ethylcellulose, FD&C Red 40 aluminum lake, hypromellose, magnesium
stearate, microcrystalline
cellulose, polyethylene glycol, polyvinyl alcohol, sodium lauryl
sulfate, talc and titanium dioxide. In
addition, the 150 mg tablet contains D&C Red 27 aluminum lake.
CLINICAL PHARMACOLOGY
The absorption of demeclocycline is slower than that of tetracycline.
The time to reach the peak
concentration is about 4 hours. After a 150 mg oral dose of
demeclocycline tablet, the mean
concentrations at 1 hour and 3 hours are 0.46 and 1.22 mcg/mL (n = 6),
respectively. The serum half-life
ranges between 10 and 16 hours. PHARMACOKINETICS
When demeclocycline hydrochloride is given concomitantly with some
dairy products, or antacids
containing aluminum, calcium, or magnesium, the extent of absorption
is reduced by more than 50%.
Demeclocycline hydrochloride penetrates well into various body fluids
and tissues. The percent of
demeclocycline hydrochloride bound to plasma protein is about 40%
using a dialysis equilibrium
m