国: マレーシア
言語: 英語
ソース: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PERINDOPRIL ERBUMINE
DUOPHARMA (M) SDN. BHD.
PERINDOPRIL ERBUMINE
30Tablet Tablets; 100Tablet Tablets
DUOPHARMA MANUFACTURING (BANGI) SDN BHD
_Consumer Medication Information Leaflet (RIMUP) _ COVAPRIL TABLET® Perindopril Erbumine 4mg WHAT IS IN THE LEAFLET? 1. What COVAPRIL is used for 2. How COVAPRIL works 3. Before you use COVAPRIL 4. How to use COVAPRIL 5. While you are using it 6. Side effects 7. Storage and Disposal of COVAPRIL 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT COVAPRIL IS USED FOR This medicine is used to: • treat high blood pressure (hypertension) • treat heart failure (a condition where the heart is unable to pump enough blood to meet the body’s needs) HOW COVAPRIL WORKS COVAPRIL tablet belongs to a group of medicines called ACE Inhibitors. These group of medicines works by widening the blood vessels. This makes it easier for your heart to pump blood through the body. BEFORE YOU USE COVAPRIL_ _ - _When you must not use it _ • if you are allergic (hypersensitive) to perindopril or to any of the other ingredients of COVAPRIL tablets or to any other ACE Inhibitor • if you have in the past suffered from acute swelling of the face, tongue or larynx (angioneuriotic syndrome), regardless of whether or not it has been caused by treatment with similar medicine (ACE Inhibitor). • if you are more than 3 months pregnant. It is also better to avoid COVAPRIL tablets in early pregnancy. Children: COVAPRIL tablets are not for use in children. - _Before you start to use it _ If you experience any of the following, please tell your doctor before you start taking COVAPRIL tablet: • if you have narrowing of the heart valves (aortic or mitral stenosis) or heart muscle disease (hypertrophic cardiomyopathy) or narrowing of the artery supplying the kidney with blood (renal artery stenosis) • if you have recently had a kidney transplant • if you have any other heart or liver or kidney problems, or if you are having dialysis • if you have diabetes which is not well controlled • if you have been told the limit the salt in your diet or to use a salt-substitute containing potassium • i 完全なドキュメントを読む
COVAPRIL TABLET 4MG [DUOPHARMA (M) SDN BHD] DESCRIPTION: An oblong, scored, white to off-white tablet. COMPOSITION: Each tablet contains: Perindopril Erbumine 4mg. PHARMACODYNAMICS: Perindopril following hydrolysis to perindoprilat, inhibits angiotensin converting enzyme (ACE) both in vitro and in vivo. It is thought that ACE inhibitors reduce blood pressure by inhibiting the enzyme which catalyses the conversion of angiotensin I to angiotensin II. Decreased plasma angiotensin II leads to increased plasma renin activity and a decrease in aldosterone. In addition to its effects on circulating ACE, Perindopril binds to, and inhibits tissue converting enzyme, predominantly in the kidney and vascular wall. The contribution of this mechanism to the overall antihypertensive effect of Perindopril is unknown. Perindopril may also inhibit the degradation of the potent vasodepressor peptide, bradykinin, and this action may contribute to its antihypertensive action. Perindopril appears to reduce peripheral resistance and may influence arterial compliance. The administration of Perindopril to patients with essential hypertension results in a reduction in supine and standing blood pressure without any significant effect on heart rate. Abrupt withdrawal of Perindopril has not been associated with a rebound rise in blood pressure. PHARMACOKINETICS: Following oral administration, Perindopril is rapidly absorbed and is 61-85% bioavailable. Elimination is rapid, occurring predominantly via the urine. Plasma t 1/2 = 1 hour. Biotransformation of perindopril to the active metabolite perindoprilat is approximately 20%. Peak plasma concentrations of perindoprilat occur 3 to 4 hours after oral administration of Perindopril and peak pharmacological activity occurs after 4 to 6 hours. Protein binding of perindoprilat is below 30%. Perindoprilat binds to plasma and tissue ACE, and free perindoprilat is eliminated through the urine. The elimination half life of the free fraction is between 3 and 5 hours. The terminal half life, which corres 完全なドキュメントを読む