CO-TRIMOXAZOLE 'MPI' TABLETS

国: マレーシア

言語: 英語

ソース: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有効成分:

TRIMETHOPRIM; SULPHAMETHOXAZOLE

から入手可能:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

INN（国際名）:

TRIMETHOPRIM; SULPHAMETHOXAZOLE

パッケージ内のユニット:

1000 Tablets

製:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

情報リーフレット

_Consumer Medication Information Leaflet (RiMUP) _
1
CO-TRIMOXAZOLE ‘MPI’ TABLETS
Sulphamethoxazole/Trimethoprim (400mg/80mg)
WHAT IS IN THIS LEAFLET:
1.
What
Co-Trimoxazole
‘MPI’
Tablets is used for
2.
How
Co-Trimoxazole
‘MPI’
Tablets works
3.
Before
you
use
Co-Trimoxazole
‘MPI’ Tablets
4.
How to use Co-Trimoxazole ‘MPI’
Tablets
5.
While
you
are
using
Co-
Trimoxazole ‘MPI’ Tablets
6.
Side Effects
7.
Storage
and
Disposal
of
Co-
Trimoxazole ‘MPI’ Tablets
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of Revision
WHAT
CO-TRIMOXAZOLE
‘MPI’
TABLETS IS USED FOR
Co-Trimoxazole
is
used
for
the
treatment
of
urinary
tract
infections,
pneumocystitis
carinii
pneumonia
(inflammation
of
lungs),
intra-
abdominal
infections,
genitourinary
tract infections, burn wound infections,
acute otitis media (inflammation of the
ear),
respiratory
tract
infections
and
various lung infections.
Your doctor may have prescribed Co-
Trimoxazole ‘MPI’ Tablets for another
purpose. Ask your doctor if you have
any
questions
why
Co-Trimoxazole
‘MPI’ Tablets has been prescribed for
you.
HOW CO-TRIMOXAZOLE ‘MPI’ TABLETS
WORKS
Co-Trimoxazole belongs to a group of
medicines
called
antibiotics.
Co-
Trimoxazole
works
by
stopping
the
growth
of
the
bacteria
causing
the
infection.
BEFORE
YOU
USE
CO-TRIMOXAZOLE
‘MPI’ TABLETS
-_When you must not use it _

If you are allergic (hypersensitive)
to trimethoprim or sulphonamide or
any
other
ingredient
of
Co-
Trimoxazole ‘MPI’ Tablets.

If
you
have
acute
porphyria
(a
genetic metabolic disorder).

If you have G6PD deficiency.

If
you
are
going
to
deliver
or
a
nursing mother.

If it is for your child and they are less
than 2 months of birth.

If you are not sure if any of the above
applies to you, talk to your doctor or
pharmacist
before
taking
Co-
Trimoxazole ‘MPI’ Tablets.
-_Before you start to use it _
You must tell your doctor or pharmacist
if:

You have allergies to any medicine
which you have taken previ

製品の特徴

7044-05
CO-TRIMOXAZOLE ‘MPI’TABLETS
NAME AND STRENGTH OF ACTIVE INGREDIENT(S):
Each tablet contains:
Sulphamethoxazole
………………………………………………400mg
Trimethoprim………………………………………………………80mg
PRODUCT DESCRIPTION:
A white, round, scored of diameter 12.5mm flat tablet with ‘MPI’
marking.
PHARMACODYNAMICS:
The antimicrobial activity of the combination of trimethoprim and
sulphamethoxazole results from its actions on two
steps of the enzymatic pathway for the synthesis of tetrahydrofolic
acid. Sulphonamide inhibits the incorporation of
PABA into folic acid, and trimethoprim prevents the reduction of
dihydrofolate to tetrahydrofolate.
PHARMACOKINETICS:
After a single oral dose of the combined preparation, trimethoprim is
absorbed more rapidly than sulphamethoxazole.
Peak blood concentrations of trimethoprim usually occur by 2 hours,
and that of sulphamethoxazole are seen by 4
hours. The half-lives of trimethoprim and sulphamethoxazole are 16 and
10 hours, respectively.
Trimethoprim is rapidly distributed and concentrated in tissues, and
relatively small quantities are bound to plasma
protein in the presence of sulphamethoxazole. The drug enters
cerebrospinal fluid and sputum readily. High
concentrations of each component of the mixture are also found in
bile. About 65% of sulphamethoxazole is bound to
plasma protein.
Up to 60% of administered trimethoprim and from 25% to 50% of
sulphamethoxazole are excreted in the urine in 24
hours. Two third of the sulphamethoxazole is unconjugated. Metabolites
of trimethoprim are also excreted.
INDICATIONS:
Co-Trimoxazole is used for the treatment of:
•
Urinary tract infections caused by E.coli, Klebsiella, Enterobacter,
P. mirabilis, P. vulgaris and Morganella
morganii.
•
Acute otitis media in children caused by H. influenzae and
Streptococcus pneumoniae.
•
Acute exacerbations of chronic bronchitis in adults caused by H.
influenzae and Streptococcus pneumoniae.
•
Enteritis caused by Shigella flexner