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CMI0085-04
1
CATAPRES® 100 TABLETS
_Clonidine Hydrochloride _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Catapres 100 tablets.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have benefits and
risks. Your doctor has weighed the
risks of you taking Catapres against
the benefits they expect it will have
for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
This leaflet was last updated on the
date at the end of this leaflet. More
recent information may be available.
The latest Consumer Medicine
Information is available from your
pharmacist, doctor, or from
www.medicines.org.au [http://www.medicines.org.au/]and may
contain important information about
the medicine and its use of which
you should be aware.
KEEP THIS LEAFLET WITH YOUR
MEDICINE.
You may need to read it again.
WHAT CATAPRES IS USED
FOR
Catapres lowers high blood pressure,
also called hypertension.
Everyone has blood pressure. This
pressure helps your blood move
around your body. Your blood
pressure may be different at different
times of the day. You have
hypertension when your blood
pressure stays higher than normal,
even when you are calm or relaxed.
There are usually no signs of
hypertension. The only way of
knowing that you have hypertension
is to have your blood pressure
checked on a regular basis. You may
feel fine and have no symptoms, but
if high blood pressure is not treated,
it can lead to serious health problems
(such as heart disease).
Catapres works by relaxing and
widening blood vessels and so helps
to lower your blood pressure.
C
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製品の特徴
PI0046b-05
1
CATAPRES
®
100 TABLETS
NAME OF THE MEDICINE
_Active ingredient:_
Clonidine hydrochloride
_Chemical name:_
2,6-dichloro-N-2-imidazolidinylidene-benzenamine hydrochloride
_Molecular formula:_
C
9
H
9
N
3
Cl
2
.HCl
_Molecular weight:_
266.56
_CAS number:_
4205-91-8
_Laboratory designation:_
ST 155
_Structural formula: _
DESCRIPTION
Clonidine hydrochloride is a white or almost white, crystalline powder. It is soluble in
ethanol, slightly soluble in chloroform and practically insoluble in ether. One gram is soluble
in 13 mL of water (20 C).
CATAPRES 100 tablets contain 100 micrograms of clonidine hydrochloride.
CATAPRES100 tablets contain the excipients maize starch, lactose, calcium hydrogen
phosphate, colloidal anhydrous silica, povidone and
stearic acid.
PHARMACOLOGY
MODE OF ACTION
Antihypertensive effect
_ _
CATAPRES is predominantly an antihypertensive agent whose mechanism of action
appears to be central alpha
2
adrenergic stimulation, as demonstrated in
animal studies. This
results in the inhibition of bulbar sympathetic cardioaccelerator and sympathetic
vasoconstrictor centres, thereby causing a decrease in sympathetic outflow from the brain.
There is an increase in vagal activity which produces a decrease in heart rate. There is also
an increase in baroreceptor activity. Additionally CATAPRES stimulates peripheral alpha
1
PI0046b-05
2
adrenergic receptors. This is reflected by a small transient pressor effect (5-10 mmHg
systolic blood pressure) following parenteral use. A transient rise in blood sugar may also
occur following
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