BISCOMIN SYRUP 4mg5ml

国: マレーシア

言語: 英語

ソース: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

有効成分:

Bromhexine HCl

から入手可能:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

INN（国際名）:

Bromhexine HCl

パッケージ内のユニット:

60ml mL

製:

MALAYSIAN PHARMACEUTICAL INDUSTRIES SDN. BHD.

情報リーフレット

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
1
BISCOMIN SYRUP
Bromhexine HCL (4mg/5ml)
WHAT IS IN THIS LEAFLET
1.
What Biscomin Syrup is used
for
2.
How Biscomin Syrup works
3.
Before
you
use
Biscomin
Syrup
4.
How to use Biscomin Syrup
5.
While you are using Biscomin
Syrup
6.
Side effects
7.
Storage
and
Disposal
of
Biscomin Syrup
8.
Product description
9.
Manufacturer
and
Product
Registration holder
10.
Date of Revision
WHAT BISCOMIN SYRUP IS USED FOR
Bromhexine
HCl
is
the
active
ingredient of Biscomin Syrup. It is
a mucolytic agent and is indicated
in
the
treatment
of
respiratory
disorders associated with viscid or
excessive mucus.
HOW BISCOMIN SYRUP WORKS
Bromhexine alters the structure of
mucus to decrease its viscocity and
therefore facilitate its removal by
ciliary action or expectoration.
BEFORE YOU USE BISCOMIN SYRUP
_- When you must not use it _

If
you
have
known
hypersensitivity
to
Bromhexine
or
any
of
its
ingredients
_ _
_- Before you start to use it _
You must tell your doctor if:

You
have
allergies
to
any
medicine
which
you
have
taken
previously
to
treat
your current condition.
_- Taking other medicines _
Always
inform
your
doctor
and
pharmacist if you are taking any
other medicines, including herbal
tonics, supplements and medicines
that you buy without prescription.
HOW TO USE BISCOMIN SYRUP
Always take this medicine exactly
as your doctor has told you. You
should check with your doctor or
pharmacist if you are not sure.
_ _
_- How much to use _
ADULTS:
8-16mg
(10-20ml)
three
times a day
CHILDREN:
6-12 years old: 4mg (5ml) three
times a day
2-6 years old: 2mg (2.5ml) three
times a day
Under 2 years old: 1mg (1.25ml)
three times a day
PAEDS:
0.3mg/kg/day 8 hourly for 7 days,
then 0.15mg/kg/day 8 hourly
_ _
_- When to use it _
Use as directed by your doctor or
pharmacist.
_ _
_- How long to use it _
Continue
taking
Biscomin
Syrup
for
as
long
as
your
doctor
recommends._ _
_ _
_- If you forget to use it _

If you forget a dose, take it as
soon as you remember it.

However, if it is n

製品の特徴

7198-02
BISCOMIN SYRUP 4MG/5ML
NAME AND STRENGTH OF ACTIVE INGREDIENT(S):
Each 5ml contains:
Bromhexine
Hydrochloride…………………………………………………4mg
PRODUCT DESCRIPTION:
A colourless to slightly pinkish colour liquid with raspberry flavour
and sweet taste.
PHARMACODYNAMICS
:
Bromhexine is an expectorant/mucolytic agent. The drug is a
benzylamine derivative (2-amino-3,5-dibromo-N-cyclohexyl N-
methylbenzylamine hydrochloride) and also a derivative of vasicine and
adhatodic acis, alkaloids obtained from the plant
Adhatoda vasica.
Following oral administration, bromhexine has increase sputum volume
and reduced the viscosity of bronchial secretions in
chronic bronchitis patients. The drug has been reported to induce
hydrolytic depolymerization of mucoprotein fibers and stimulate
activity of the ciliated epithelium. An increase in lysosomal activity
facilitated by bromhexine has been postulated. Improvements
in pulmonary function in bronchitis patients appear secondary to
easier expectoration.
An effect
of
bromhexine on increasing sputum concentrations of
various antibiotics (e.g., oxytetracycline, erythromycin,
ampicillin, amoxicillin) has also been reported. However, some of
these effects (exocrine stimulation, increased sputum
concentrations) have not been confirmed in some studies.
It has been suggested that a metabolite of bromhexine, ambroxol, may
contribute to enhanced secretion from exocrine glands
during bromhexine administration.
PHARMACOKINETICS:
ABSORPTION
Oral, well absorbed. Rapidly absorbed from the gastrointestinal tract.
Peak plasma concentrations occur after about 1 hour
following oral administration.
DISTRIBUTION
It is widely distributed to body tissues. Bromhexine is highly bound
to plasma proteins. Bromhexine crosses blood-brain barrier
and small amounts cross the placenta.
METABOLISM
Bromhexine undergoes extensive first-pass metabolism in the liver.
Ambroxol is a metabolite of bromhexine.
EXCRETION
Bromhexine is excreted primarily in the urine as metabolites. Only
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