情報リーフレット
BAXTER IRINOTECAN (irinotecan hydrochloride)
Consumer Medicine Information
BAXTER IRINOTECAN CMI 090107
Page 1 of 5
Baxter
BAXTER IRINOTECAN
_Irinotecan hydrochloride _
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about
Irinotecan hydrochloride
concentrated injection.
It does not contain all the
available information.
It does not take the place of
talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has
weighed the risks of you taking
Irinotecan hydrochloride
concentrated injection against
the benefits they expect it will
have for you.
ASK YOUR DOCTOR IF YOU HAVE
ANY CONCERNS ABOUT BEING
TREATED WITH THIS MEDICINE.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT IRINOTECAN
HYDROCHLORIDE CONCENTRATED
INJECTION IS USED FOR
Irinotecan hydrochloride
concentrated injection is used to
treat bowel cancer which has
spread to other parts of the body.
Cancer which has spread cannot
be treated by surgery alone and
one of the options in this
situation is treatment with an
anticancer medicine, known as
chemotherapy.
Alternatively, Irinotecan
hydrochloride concentrated
injection is used alone when the
cancer has not responded or has
returned after initial treatment.
Irinotecan hydrochloride
concentrated injection is
specially developed to target
cancer cells rather than normal,
healthy cells.
ASK YOUR DOCTOR IF YOU HAVE
ANY QUESTIONS ABOUT WHY
IRINOTECAN HYDROCHLORIDE
CONCENTRATED INJECTION HAS
BEEN PRESCRIBED FOR YOU. Your
doctor may have prescribed
Irinotecan hydrochloride
concentrated injection for
another purpose.
Irinotecan hydrochloride
concentrated injection is not
addictive.
This medicine is available only
with a doctor
完全なドキュメントを読む
製品の特徴
1
PRODUCT INFORMATION
BAXTER
IRINOTECAN HYDROCHLORIDE
CONCENTRATED INJECTION
NAME OF THE MEDICINE:
Non-proprietary name: Irinotecan hydrochloride concentrated injection
Chemical name: (4_S_)-4, 11-diethyl-4-hydroxy-9-[(4-
piperidinopiperidino)carbonyloxy]-1_H_-pyrano[3', 4':6, 7]indolizino[1, 2-
_b_]quinoline-3, 14(4_H_, 12_H_)dione hydrochloride trihydrate
CAS Number: CAS-136572-09-3
Irinotecan hydrochloride is
a pale yellow to yellow crystalline powder, with the
empirical formula C
33
H
38
N
4
O
6
•HCl•3H
2
O and a molecular weight of 677.19.
Irinotecan hydrochloride is slightly soluble in water
and organic solvents.
DESCRIPTION:
Irinotecan hydrochloride is
an antineoplastic agent of the topoisomerase I
inhibitor class.
Irinotecan hydrochloride is a semisynthetic
derivative of camptothecin, an
alkaloid extract from plants such as _Camptotheca acuminata._
Irinotecan hydrochloride concentrated injection is supplied as
a sterile, pale
yellow, clear, aqueous solution of pH 3.5. It is intended for
dilution with 5%
Glucose Injection (_preferred_) or
0.9% Sodium Chloride Injection prior to
infusion.
In addition to irinotecan hydrochloride, the ingredients are
sorbitol, lactic acid,
sodium hydroxide and water for injections.
2
PHARMACOLOGY:
Irinotecan hydrochloride is
a derivative of camptothecin. Camptothecins
interact specifically with the enzyme topoisomerase I which relieves
torsional
strain in DNA by inducing reversible single-strand breaks. Irinotecan
hydrochloride and its active metabolite SN-38 bind to the topoisomerase I -
DNA complex and prevent religation of these single-strand breaks. Current
research suggests that the cytotoxicity of irinotecan hydrochloride is due to
double-strand DNA damage produced during DNA synthesis
when replicati
完全なドキュメントを読む