ATENOLOL AND CHLORTHALIDONE tablet

国: アメリカ合衆国

言語: 英語

ソース: NLM (National Library of Medicine)

有効成分:

ATENOLOL (UNII: 50VV3VW0TI) (ATENOLOL - UNII:50VV3VW0TI)

から入手可能:

Lake Erie Medical DBA Quality Care Products LLC

INN（国際名）:

ATENOLOL

構図:

ATENOLOL 100 mg

処方タイプ:

PRESCRIPTION DRUG

認証ステータス:

Abbreviated New Drug Application

製品の特徴

ATENOLOL AND CHLORTHALIDONE- ATENOLOL AND CHLORTHALIDONE TABLET
LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC
----------
DESCRIPTION
Atenolol and chlorthalidone tablets, USP are for the treatment of
hypertension. They combine the
antihypertensive activity of two agents: a beta -selective
(cardioselective) hydrophilic blocking agent
(atenolol) and a monosulfonamyl diuretic (chlorthalidone). Atenolol,
USP is Benzeneacetamide, 4-[2’-
hydroxy-3’-[(1-methylethyl)amino]propoxy]-. Its structural formula
is:
C
H N O M.W. 266.34
C
H N O M.W. 266.34
Atenolol (free base) is a relatively polar hydrophilic compound with a
water solubility of 26.5 mg/mL
at 37°C. It is freely soluble in 1N HCl (300 mg/mL at 25°C) and less
soluble in chloroform (3 mg/mL at
25°C).
Chlorthalidone, USP is 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)
benzene sulfonamide. Its
structural formula is:
C
H CLN O S M.W. 338.76
C
H CLN O S M.W. 338.76
Chlorthalidone has a water solubility of 12 mg/100 mL at 20°C.
Each tablet, for oral administration, contains: 50 mg of atenolol and
25 mg of chlorthalidone or 100 mg
of atenolol and 25 mg of chlorthalidone.
In addition, each tablet contains the following inactive ingredients:
colloidal silicon dioxide, magnesium
stearate, microcrystalline cellulose, pregelatinized starch, sodium
lauryl sulfate, sodium starch
glycolate and stearic acid.
1
14
22
2
3
14
22
2
3
14
11
2
4
14
11
2
4
CLINICAL PHARMACOLOGY
ATENOLOL AND CHLORTHALIDONE
Atenolol and chlorthalidone have been used singly and concomitantly
for the treatment of hypertension.
The antihypertensive effects of these agents are additive, and studies
have shown that there is no
interference with bioavailability when these agents are given together
in the single combination tablet.
Therefore, this combination provides a convenient formulation for the
concomitant administration of
these two entities. In patients with more severe hypertension,
atenolol and chlorthalidone may be
administered with other antihypertensives such as vasodilators.
ATENOLOL
Atenol