国: オーストラリア
言語: 英語
ソース: Department of Health (Therapeutic Goods Administration)
amoxicillin trihydrate
Alphapharm Pty Ltd
Medicine Registered
Registered
PRODUCT INFORMATION ALPHAMOX _Amoxicillin (as trihydrate) _ NAME OF THE MEDICINE Active ingredient : Amoxicillin (as trihydrate) Chemical name : (2 _S_ ,5 _R_ ,6 _R_ )-6-[[(2 _R_ )-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7- oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Structural formula : Molecular formula : C 16 H 19 N 3 O 5 S, 3H 2 O Molecular weight : 419.5 CAS Registry no. : 61336-70-7 DESCRIPTION Amoxicillin trihydrate is a white or almost white, crystalline powder, which is slightly soluble in water and in ethanol (96%) and is practically insoluble in chloroform, in ether, and in fixed oils. Each ALPHAMOX 250 and ALPHAMOX 500 capsule contains amoxicillin trihydrate equivalent to 250 mg and 500 mg amoxicillin, respectively. The capsules also contain the following inactive ingredients: purified talc, magnesium stearate, sodium starch glycollate, colloidal anhydrous silica, sodium lauryl sulfate, gelatin, titanium dioxide, brilliant blue FCF CI42090, iron oxide yellow CI77492, microcrystalline cellulose [ALPHAMOX 250 only]. Each bottle of ALPHAMOX 125 suspension contains 125 mg per 5 mL of amoxicillin when reconstituted. Each bottle of ALPHAMOX 250 suspension contains 250 mg per 5 mL of amoxicillin when reconstituted. The suspensions also contain the following inactive ingredients: sodium benzoate, propylene glycol alginate, colloidal anhydrous silica, aspartame, disodium edetate, sodium citrate dihydrate, sorbitol, Raspberry Flavour Permaseal 10458-31. PHARMACOLOGY MICROBIOLOGY Amoxicillin is similar to ampicillin in its bactericidal action against Gram-positive and Gram-negative susceptible organisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of the cell wall mucopeptide. Amoxicillin is active in vitro against most strains of _Haemophilus influenzae_ *, _Neisseria gonorrhoeae_ * , _Neisseria meningitidis_ , _Escherichia coli_ * , _Proteus mirabilis_ * and Salmonellae. Because amoxicillin does not resist destruction by penicillinase, it i 完全なドキュメントを読む