Nazione: Stati Uniti
Lingua: inglese
Fonte: NLM (National Library of Medicine)
triamcinolone acetonide (UNII: F446C597KA) (triamcinolone - UNII:1ZK20VI6TY)
Aventis Pharmaceuticals Inc.
triamcinolone acetonide
55 ug
PRESCRIPTION DRUG
NASACORT HFA- TRIAMCINOLONE ACETONIDE AEROSOL, METERED AVENTIS PHARMACEUTICALS INC. ---------- NASACORT HFA [NA' ZA-CORT] (TRIAMCINOLONE ACETONIDE) NASAL AEROSOL FOR INTRANASAL USE ONLY SHAKE WELL BEFORE USING DESCRIPTION Triamcinolone acetonide, USP, the active ingredient in NASACORT HFA NASAL AEROSOL, is a glucocorticosteroid with a molecular weight of 434.5, the chemical designation 9-Fluoro- 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone (C H FO ), and the following chemical structure: Triamcinolone acetonide is a white to cream-colored crystalline powder, practically insoluble in water, very soluble in dehydrated alcohol, chloroform, and methyl alcohol. Nasacort HFA Nasal Aerosol is a metered-dose aerosol unit containing a microcrystalline suspension of triamcinolone acetonide in tetrafluoroethane (HFA-134a) and dehydrated alcohol USP 0.7% w/w. Each canister contains 15 mg of triamcinolone acetonide. The canister must be primed with 3 actuations prior to the first use or after a period of non-use (3 days). After priming, each actuation meters 100 mcg of triamcinolone acetonide in 65 mg of suspension from the valve and delivers 55 mcg of triamcinolone acetonide from the nasal actuator to the patient. If the product is not used for more than 3 days, it should be re-primed with 3 actuations. Each 9.3 g canister of Nasacort HFA Nasal Aerosol provides 100 metered sprays. After 100 metered sprays, this amount of medication delivered per actuation may not be consistent and the unit should be discarded. Patients are provided with a check-off card to track usage as part of the PATIENT'S INSTRUCTIONS FOR USE tear-off sheet. CLINICAL PHARMACOLOGY Triamcinolone acetonide, a synthetic glucocorticosteroid, is a more potent derivative of triamcinolone. Although triamcinolone itself is approximately 1 to 2 times as potent as prednisone in animal models of inflammation, triamcinolone acetonide is approximately 8 times more potent than prednisone. The clinical relevance of _in vitro_ Leggi il documento completo