NASACORT HFA triamcinolone acetonide aerosol metered

Страна: САЩ

Език: английски

Източник: NLM (National Library of Medicine)

Активна съставка:

triamcinolone acetonide (UNII: F446C597KA) (triamcinolone - UNII:1ZK20VI6TY)

Предлага се от:

Aventis Pharmaceuticals Inc.

INN (Международно Name):

triamcinolone acetonide

Композиция:

55 ug

Вид предписание :

PRESCRIPTION DRUG

Данни за продукта

NASACORT HFA- TRIAMCINOLONE ACETONIDE AEROSOL, METERED
AVENTIS PHARMACEUTICALS INC.
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NASACORT HFA
[NA' ZA-CORT]
(TRIAMCINOLONE ACETONIDE)
NASAL AEROSOL
FOR INTRANASAL USE ONLY
SHAKE WELL BEFORE USING
DESCRIPTION
Triamcinolone acetonide, USP, the active ingredient in NASACORT HFA NASAL AEROSOL, is a
glucocorticosteroid with a molecular weight of 434.5, the chemical
designation 9-Fluoro-
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic
16,17-acetal with acetone
(C
H FO ), and the following chemical structure:
Triamcinolone acetonide is a white to cream-colored crystalline
powder, practically insoluble in water,
very soluble in dehydrated alcohol, chloroform, and methyl alcohol.
Nasacort HFA Nasal Aerosol is a metered-dose aerosol unit containing a
microcrystalline suspension
of triamcinolone acetonide in tetrafluoroethane (HFA-134a) and
dehydrated alcohol USP 0.7% w/w.
Each canister contains 15 mg of triamcinolone acetonide.
The canister must be primed with 3 actuations prior to the first use
or after a period of non-use (3 days).
After priming, each actuation meters 100 mcg of triamcinolone
acetonide in 65 mg of suspension from
the valve and delivers 55 mcg of triamcinolone acetonide from the
nasal actuator to the patient. If the
product is not used for more than 3 days, it should be re-primed with
3 actuations.
Each 9.3 g canister of Nasacort HFA Nasal Aerosol provides 100 metered
sprays. After 100 metered
sprays, this amount of medication delivered per actuation may not be
consistent and the unit should be
discarded. Patients are provided with a check-off card to track usage
as part of the PATIENT'S
INSTRUCTIONS FOR USE tear-off sheet.
CLINICAL PHARMACOLOGY
Triamcinolone acetonide, a synthetic glucocorticosteroid, is a more
potent derivative of triamcinolone.
Although triamcinolone itself is approximately 1 to 2 times as potent
as prednisone in animal models of
inflammation, triamcinolone acetonide is approximately 8 times more
potent than prednisone. The
clinical relevance of _in vitro_