Nazione: Australia
Lingua: inglese
Fonte: Department of Health (Therapeutic Goods Administration)
methylprednisolone sodium succinate
Alphapharm Pty Ltd
methylprednisolone sodium succinate
Registered
METHYLPREDNISOLONE ALPHAPHARM POWDER FOR INJECTION _Methylprednisolone (as sodium succinate) _ PRODUCT INFORMATION NAME OF THE MEDICINE Active ingredient : Methylprednisolone sodium succinate Chemical name : Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6- methyl-,monosodium salt,(6α,11β) Structural formula : Molecular formula : C 26 H 33 NaO 8 Molecular weight : 496.53 CAS Registry no. : 2375-03-3 DESCRIPTION Methylprednisolone Alphapharm contains methylprednisolone sodium succinate, a synthetic glucocorticoid. It occurs as a white or nearly white, odourless, hygroscopic, amorphous solid. It is very soluble in water and in alcohol; it is insoluble in chloroform and is very slightly soluble in acetone. Methylprednisolone sodium succinate is so extremely soluble in water that it may be administered in a small volume of diluent and is especially well suited for intravenous use in situations in which high blood levels of methylprednisolone are required rapidly. Methylprednisolone Alphapharm 40 mg, powder for injection (IM-IV) contains the active ingredient, methylprednisolone. It also contains the following excipients: sodium phosphate monobasic anhydrous, sodium phosphate dibasic anhydrous, sodium hydroxide and lactose anhydrous. It is intended for intramuscular or intravenous administration. Methylprednisolone Alphapharm 500 mg and 1 g, powder for injection (IV) contain the active ingredient, methylprednisolone. They also contain the following excipients: sodium phosphate monobasic anhydrous, sodium phosphate dibasic anhydrous and sodium hydroxide, and are indicated for intravenous administration only. METHYLPREDNISOLONE ALPHAPHARM – Product Information 2 PHARMACOLOGY PHARMACODYNAMICS Methylprednisolone is a potent anti-inflammatory steroid, with greater anti-inflammatory potency and even less sodium and water retention inducing tendency than prednisolone. Methylprednisolone sodium succinate has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parente Leggi il documento completo