METHYLPREDNISOLONE ALPHAPHARM methylprednisolone (as sodium succinate) 40 mg powder for injection vial

Land: Australien

Sprache: Englisch

Quelle: Department of Health (Therapeutic Goods Administration)

Wirkstoff:

methylprednisolone sodium succinate

Verfügbar ab:

Alphapharm Pty Ltd

INN (Internationale Bezeichnung):

methylprednisolone sodium succinate

Berechtigungsstatus:

Registered

Fachinformation

METHYLPREDNISOLONE ALPHAPHARM
POWDER FOR INJECTION
_Methylprednisolone (as sodium succinate) _
PRODUCT INFORMATION
NAME OF THE MEDICINE
Active ingredient
:
Methylprednisolone sodium succinate
Chemical name
:
Pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-
methyl-,monosodium salt,(6α,11β)
Structural formula
:
Molecular formula
:
C
26
H
33
NaO
8
Molecular weight
:
496.53
CAS Registry no.
:
2375-03-3
DESCRIPTION
Methylprednisolone Alphapharm contains methylprednisolone sodium
succinate, a synthetic glucocorticoid. It
occurs as a white or nearly white, odourless, hygroscopic, amorphous
solid. It is very soluble in water and in
alcohol; it is insoluble in chloroform and is very slightly soluble in
acetone.
Methylprednisolone sodium succinate is so extremely soluble in water
that it may be administered in a small
volume of diluent and is especially well suited for intravenous use in
situations in which high blood levels of
methylprednisolone are required rapidly.
Methylprednisolone
Alphapharm
40
mg,
powder
for
injection
(IM-IV)
contains
the
active
ingredient,
methylprednisolone. It also contains the following excipients: sodium
phosphate monobasic anhydrous, sodium
phosphate dibasic anhydrous, sodium hydroxide and lactose anhydrous.
It is intended for intramuscular or
intravenous administration.
Methylprednisolone Alphapharm 500 mg and 1 g, powder for injection
(IV) contain the active ingredient,
methylprednisolone. They also contain the following excipients: sodium
phosphate monobasic anhydrous,
sodium phosphate dibasic anhydrous and sodium hydroxide, and are
indicated for intravenous administration
only.
METHYLPREDNISOLONE ALPHAPHARM – Product Information
2
PHARMACOLOGY
PHARMACODYNAMICS
Methylprednisolone is a potent anti-inflammatory steroid, with greater
anti-inflammatory potency and even less
sodium and water retention inducing tendency than prednisolone.
Methylprednisolone
sodium
succinate
has
the
same
metabolic
and
anti-inflammatory
actions
as
methylprednisolone. When given parente