Nazione: Stati Uniti
Lingua: inglese
Fonte: NLM (National Library of Medicine)
FUROSEMIDE (UNII: 7LXU5N7ZO5) (FUROSEMIDE - UNII:7LXU5N7ZO5)
MWI/VetOne
FUROSEMIDE
FUROSEMIDE 50 mg in 1 mL
INTRAMUSCULAR
PRESCRIPTION
Dogs and Horses: Furosemide Injection is an effective diuretic-saluretic for use in the treatment of acute noninflammatory tissue edema in dogs and horses, and for use in the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency in the dog. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy in either dogs or horses is determined by the clinical pathology producing the edema. Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant bitches, mares and stallions at stud. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. Monitor serum electrolytes, BUN and CO2 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia. Corticosteroids cause an additive potassium-depletion effect.
Furosemide Injection, 50 mg/mL is supplied in 100 mL multi-dose vials. NDC 13985-581-10 – 100 mL
New Animal Drug Application
FUROSEMIDE- FUROSEMIDE INJECTION MWI/VETONE ---------- FUROSEMIDE INJECTION 50 MG/ML Approved by FDA under NADA # 131-538 CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION: Furosemide is a potent loop diuretic which is a derivative of anthranilic acid. The structure is: Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid. Furosemide is pharmacodynamically characterized by the following. 1) Administered intramuscularly, it begins to act in about 30 minutes, and diuretic response is produced. When administered intravenously, the response is in about 5 minutes. 2) Is a loop diuretic which inhibits reabsorption of sodium and chloride at the ascending loop of Henle in the kidneys, enhancing water excretion. 3) A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold. 4) A high degree of efficacy, low inherent toxicity and a high therapeutic index. EACH ML CONTAINS: 50 mg furosemide as a monoethanolamine salt, myristyl-gamma- picolinium chloride 0.02%, EDTA sodium 0.1%, sodium sulfite 0.1% with sodium chloride 0.2% in water for injection, pH adjusted with sodium hydroxide and/or hydrochloric acid. ACTIONS: The therapeutic efficacy of Furosemide Injection is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug’s rapid absorption and a poor lipid 1 2 3 1 solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. Furosemide has no inhibitory effect on carbonic anhydrase or aldosterone activity in the distal tubule. The drug possesses diuretic activity either in the presence of acidosis or alkalosis. INDICATIONS: Dogs and Horses: Furosemide Injection is an effective diuretic-saluretic for use in the treatment of Leggi il documento completo