FUROSEMIDE injection

Χώρα: Ηνωμένες Πολιτείες

Γλώσσα: Αγγλικά

Πηγή: NLM (National Library of Medicine)

Δραστική ουσία:

FUROSEMIDE (UNII: 7LXU5N7ZO5) (FUROSEMIDE - UNII:7LXU5N7ZO5)

Διαθέσιμο από:

MWI/VetOne

INN (Διεθνής Όνομα):

FUROSEMIDE

Σύνθεση:

FUROSEMIDE 50 mg in 1 mL

Οδός χορήγησης:

INTRAMUSCULAR

Τρόπος διάθεσης:

PRESCRIPTION

Θεραπευτικές ενδείξεις:

Dogs and Horses: Furosemide Injection is an effective diuretic-saluretic for use in the treatment of acute noninflammatory tissue edema in dogs and horses, and for use in the treatment of edema (pulmonary congestion, ascites) associated with cardiac insufficiency in the dog. In cases of edema involving cardiac insufficiency, the continued use of heart stimulants such as digitalis or its glycosides is indicated. The rationale for efficacious use of diuretic therapy in either dogs or horses is determined by the clinical pathology producing the edema. Animal reproductive studies have shown that furosemide may cause fetal abnormality and the drug is contraindicated in pregnant bitches, mares and stallions at stud. Furosemide is contraindicated in anuria, furosemide hypersensitivity, hepatic coma, or during electrolytic imbalances. Monitor serum electrolytes, BUN and CO2 frequently. Monitor serum potassium levels and watch for signs of hypocalcemia. Corticosteroids cause an additive potassium-depletion effect.

Περίληψη προϊόντος:

Furosemide Injection, 50 mg/mL is supplied in 100 mL multi-dose vials. NDC 13985-581-10 – 100 mL

Καθεστώς αδειοδότησης:

New Animal Drug Application

Αρχείο Π.Χ.Π.

FUROSEMIDE- FUROSEMIDE INJECTION
MWI/VETONE
----------
FUROSEMIDE INJECTION
50 MG/ML
Approved by FDA under NADA # 131-538
CAUTION:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION:
Furosemide is a potent loop diuretic which is a derivative of
anthranilic acid. The
structure is:
Chemical Name: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid.
Furosemide is
pharmacodynamically characterized by the following.
1) Administered intramuscularly, it begins to act in about 30 minutes,
and diuretic
response is produced. When administered intravenously, the response is
in about 5
minutes.
2) Is a loop diuretic which inhibits reabsorption of sodium and
chloride at the ascending
loop of Henle in the kidneys, enhancing water excretion.
3) A dose-response relationship and a ratio of minimum to maximum
effective dose
range greater than tenfold.
4) A high degree of efficacy, low inherent toxicity and a high
therapeutic index.
EACH ML CONTAINS: 50 mg furosemide as a monoethanolamine salt,
myristyl-gamma-
picolinium chloride 0.02%, EDTA sodium 0.1%, sodium sulfite 0.1% with
sodium chloride
0.2% in water for injection, pH adjusted with sodium hydroxide and/or
hydrochloric acid.
ACTIONS:
The therapeutic efficacy of Furosemide Injection is from the activity
of the intact and
unaltered molecule throughout the nephron, inhibiting the reabsorption
of sodium not
only in the proximal and distal tubule but also in the ascending limb
of the loop of Henle.
The prompt onset of action is a result of the drug’s rapid
absorption and a poor lipid
1 2
3
1
solubility. The low lipid solubility and a rapid renal excretion
minimize the possibility of its
accumulation in tissues and organs or crystalluria. Furosemide has no
inhibitory effect
on carbonic anhydrase or aldosterone activity in the distal tubule.
The drug possesses
diuretic activity either in the presence of acidosis or alkalosis.
INDICATIONS:
Dogs and Horses: Furosemide Injection is an effective
diuretic-saluretic for use in the
treatment of