Negara: Malaysia
Bahasa: Inggris
Sumber: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
METHIMAZOLE
IMEKS PHARMA SDN. BHD.
METHIMAZOLE
100Tablet Tablets; 30Tablet Tablets; 200Tablet Tablets; 50Tablet Tablets; 500Tablet Tablets
Sriprasit Pharma Co. Ltd.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ TIMAZOL TABLET 5MG Methimazole (5mg) _ _ 1 WHAT IS IN THE LEAFLET 1. What TIMAZOL is used for 2. How TIMAZOL works 3. Before you use TIMAZOL 4. How to use TIMAZOL 5. While you are using it 6. Side effects 7. Storage and Disposal of TIMAZOL 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT TIMAZOL IS USED FOR TIMAZOL is used to treat hyperthyroidism or overactive thyroid gland (a condition where the thyroid gland produces too much thyroid hormone). It is also used before thyroid surgery or radioactive iodine treatment. Ask your doctor if you have any questions about why this medicine was prescribed for you. Your doctor may have prescribed it for another reason. HOW TIMAZOL WORKS TIMAZOL contains the active ingredient Methimazole which belongs to a group of medicines called antithyroid agents. It works by reducing the amount of thyroid hormones made in your thyroid gland. BEFORE YOU USE TIMAZOL_ _ - _When you must not use it_ Do not take TIMAZOL if: • You are allergic to methimazole or any ingredients in the formulation or any other similar medicines. • You are breastfeeding or planning to breastfeed. TIMAZOL may passes into the mother’s milk. • You had inflammation of the pancreas (acute pancreatitis) after administration of carbimazole or methimazole (thiamazole) in the past. _If you are not sure whether you should start _ _taking this medicine, talk to your doctor. _ - _Before you start to use it _ Tell your doctor if: • You have allergies to any other medicines, food, preservatives or dyes. • You have a low white blood cell count. • You have joint pain. • You have liver problems. • You are taking medications that are known to cause agranulocytosis (decrease in white blood cell count). • You are allergic to carbimazole or propylthiouracil (other thyroid medications). • TIMAZOL can cause harm to an unborn baby. If you can get pregnant, use reliable contraception from the time you start treatment Baca dokumen lengkapnya
140 mm 205 mm 145X205 MM 1COLOR JOB NAME ิ ธ ทิ ส ะ ร ปี ร ศ ม ร ร ก ชั ส ภ เ ร ท นิ น า ธ ยศ 18/10/64 CONTENT Each tablet contains Methimazole 5mg. DESCRIPTION White round biconvex tablet with a bisect on one side and embossed with “S03” on the other. PROPERTIES PHARMACODYNAMICS Methimazole (also known as thiamazole) is an antithyroid drug that acts by blocking the production of thyroid hormones through 2 mechanisms i.e. by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin; and also by inhibiting the coupling of these iodotyrosyl residues to form iodothyronine. Methimazole does not inhibit the action of thyroid hormones that are already formed and present in the thyroid gland or circulation, nor does the drug interfere with the effectiveness of exogenously administered thyroid hormones. Methimazole is at least 10 times more potent than propylthiouracil on a weight basis. PHARMACOKINETICS The pharmacokinetics of methimazole can be considered together with those of carbimazole since carbimazole is rapidly and completely metabolised to methimazole in the body. Following oral administration, methimazole is rapidly absorbed from the gastrointestinal tract with peak plasma concentrations occurring within about 30 to 60 minutes. It is metabolised rapidly and the elimination half-life ranges from 5 – 13 hours. Methimazole is excreted in urine. INDICATION TIMAZOL is indicated in the treatment of hyperthyroidism. Long-term therapy may lead to remission of the disease. TIMAZOL may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy. RECOMMENDED DOSAGE TIMAZOL is administered orally and daily dosage is usually given in 3 divided doses at approximately 8-hour intervals. Adult: • Mild hyperthyroidism: 3 tablets (15mg) daily in 3 divided doses. • Moderately severe hyperthyroidism: 6 – 8 tablets (30 – 40mg) daily in 3 divided doses. • Severe hyperthyroi Baca dokumen lengkapnya