Timazol Tablet 5mg

البلد: ماليزيا

اللغة: الإنجليزية

المصدر: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

العنصر النشط:

METHIMAZOLE

متاح من:

IMEKS PHARMA SDN. BHD.

INN (الاسم الدولي):

METHIMAZOLE

الوحدات في الحزمة:

100Tablet Tablets; 30Tablet Tablets; 200Tablet Tablets; 50Tablet Tablets; 500Tablet Tablets

المصنعة من قبل:

Sriprasit Pharma Co. Ltd.

نشرة المعلومات

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
TIMAZOL TABLET 5MG
Methimazole (5mg)
_ _
1
WHAT IS IN THE LEAFLET
1.
What TIMAZOL is used for
2.
How TIMAZOL works
3.
Before you use TIMAZOL
4.
How to use TIMAZOL
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of TIMAZOL
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision
WHAT TIMAZOL IS USED FOR
TIMAZOL is used to treat hyperthyroidism
or
overactive
thyroid
gland
(a
condition
where the thyroid gland produces too much
thyroid
hormone).
It
is
also
used
before
thyroid
surgery
or
radioactive
iodine
treatment.
Ask your doctor if you have any questions
about why this medicine was prescribed for
you. Your doctor may have prescribed it for
another reason.
HOW TIMAZOL WORKS
TIMAZOL
contains
the
active
ingredient
Methimazole which belongs to a group of
medicines called antithyroid agents. It works
by reducing the amount of thyroid hormones
made in your thyroid gland.
BEFORE YOU USE TIMAZOL_ _
-
_When you must not use it_
Do not take TIMAZOL if:
• You are allergic to methimazole or any
ingredients in the formulation or any other
similar medicines.
•
You
are
breastfeeding
or
planning
to
breastfeed. TIMAZOL may passes into the
mother’s milk.
•
You
had
inflammation
of
the
pancreas
(acute
pancreatitis)
after
administration
of
carbimazole or methimazole (thiamazole) in
the past.
_If you are not sure whether you should start _
_taking this medicine, talk to your doctor. _
-
_Before you start to use it _
Tell your doctor if:
• You have allergies to any other medicines,
food, preservatives or dyes.
• You have a low white blood cell count.
• You have joint pain.
• You have liver problems.
• You are taking medications that are known
to cause agranulocytosis (decrease in white
blood cell count).
•
You
are
allergic
to
carbimazole
or
propylthiouracil (other thyroid medications).
• TIMAZOL can cause harm to an unborn
baby. If you can get pregnant, use reliable
contraception
from
the
time
you
start
treatment

خصائص المنتج

140 mm
205 mm
145X205 MM 1COLOR
JOB NAME
ิ
ธ
ทิ
ส
ะ
ร
ปี
ร
ศ
ม
ร
ร
ก
ชั
ส
ภ
เ

ร
ท
นิ
น
า
ธ
ยศ
18/10/64
CONTENT
Each tablet contains Methimazole 5mg.
DESCRIPTION
White round biconvex tablet with a bisect on one side and embossed
with
“S03” on the other.
PROPERTIES
PHARMACODYNAMICS
Methimazole (also known as thiamazole) is an antithyroid drug that
acts by
blocking the production of thyroid hormones through 2 mechanisms i.e.
by
interfering with the incorporation of iodine into tyrosyl residues of
thyroglobulin; and also by inhibiting the coupling of these
iodotyrosyl
residues to form iodothyronine.
Methimazole does not inhibit the action of thyroid hormones that are
already formed and present in the thyroid gland or circulation, nor
does the drug interfere with the effectiveness of exogenously
administered
thyroid hormones. Methimazole is at least 10 times more potent than
propylthiouracil on a weight basis.
PHARMACOKINETICS
The pharmacokinetics of methimazole can be considered together with
those of carbimazole since carbimazole is rapidly and completely
metabolised to methimazole in the body.
Following oral administration, methimazole is rapidly absorbed from
the
gastrointestinal tract with peak plasma concentrations occurring
within
about 30 to 60 minutes. It is metabolised rapidly and the elimination
half-life ranges from 5 – 13 hours. Methimazole is excreted in
urine.
INDICATION
TIMAZOL is indicated in the treatment of hyperthyroidism. Long-term
therapy may lead to remission of the disease. TIMAZOL may also be used
to ameliorate hyperthyroidism in preparation for subtotal
thyroidectomy
or radioactive iodine therapy.
RECOMMENDED DOSAGE
TIMAZOL is administered orally and daily dosage is usually given in 3
divided doses at approximately 8-hour intervals.
Adult:
• Mild hyperthyroidism: 3 tablets (15mg) daily in 3 divided doses.
• Moderately severe hyperthyroidism: 6 – 8 tablets (30 – 40mg)
daily
in 3 divided doses.
• Severe hyperthyroi