Negara: Amerika Serikat
Bahasa: Inggris
Sumber: NLM (National Library of Medicine)
AMILORIDE HYDROCHLORIDE (UNII: FZJ37245UC) (AMILORIDE - UNII:7DZO8EB0Z3)
Avera McKennan Hospital
AMILORIDE HYDROCHLORIDE
AMILORIDE HYDROCHLORIDE ANHYDROUS 5 mg
PRESCRIPTION DRUG
Abbreviated New Drug Application
AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE- AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE TABLET AVERA MCKENNAN HOSPITAL ---------- DESCRIPTION Amiloride hydrochloride and hydrochlorothiazide tablets, USP combine the potassium-conserving action of amiloride hydrochloride with the natriuretic action of hydrochlorothiazide. Amiloride hydrochloride is designated chemically as 3,5-diamino-6-chloro-_N_- (diaminomethylene)pyrazinecarboxamide monohydrochloride, dihydrate. It has the following structural formula: C H CLN O•HCL•2H O MW = 302.12 Hydrochlorothiazide is designated chemically as 6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7- sulfonamide 1,1-dioxide. It has the following structural formula: C H CLN O S MW = 297.74 It is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution. Each tablet, for oral administration, contains 5 mg of amiloride hydrochloride, USP (calculated on the anhydrous basis) and 50 mg of hydrochlorothiazide, USP. In addition, each tablet contains the following inactive ingredients: croscarmellose sodium, FD&C Yellow No. 6 Aluminum Lake, lactose monohydrate, magnesium stearate, pregelatinized starch, and sodium lauryl sulfate. CLINICAL PHARMACOLOGY Amiloride hydrochloride and hydrochlorothiazide tablets provide diuretic and antihypertensive activity (principally due to the hydrochlorothiazide component), while acting through the amiloride component to prevent the excessive potassium loss that may occur in patients receiving a thiazide diuretic. Due to its amiloride component, the urinary excretion of magnesium is less with amiloride and hydrochlorothiazide than with a thiazide or loop diuretic used alone (see PRECAUTIONS). The onset of the diuretic action of this product is within 1 to 2 hours and this action appears to be sustained for approximately 24 hours. AMILORIDE HYDROCHLORIDE 6 8 7 2 7 8 3 4 2 Amiloride hydrochloride is a potassium-conserving (antikaliuretic) drug that possesses weak (compare Baca dokumen lengkapnya