AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE tablet

Страна: САЩ

Език: английски

Източник: NLM (National Library of Medicine)

Активна съставка:

AMILORIDE HYDROCHLORIDE (UNII: FZJ37245UC) (AMILORIDE - UNII:7DZO8EB0Z3)

Предлага се от:

Avera McKennan Hospital

INN (Международно Name):

AMILORIDE HYDROCHLORIDE

Композиция:

AMILORIDE HYDROCHLORIDE ANHYDROUS 5 mg

Вид предписание :

PRESCRIPTION DRUG

Статус Оторизация:

Abbreviated New Drug Application

Данни за продукта

AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE- AMILORIDE
HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE TABLET
AVERA MCKENNAN HOSPITAL
----------
DESCRIPTION
Amiloride hydrochloride and hydrochlorothiazide tablets, USP combine
the potassium-conserving
action of amiloride hydrochloride with the natriuretic action of
hydrochlorothiazide.
Amiloride hydrochloride is designated chemically as
3,5-diamino-6-chloro-_N_-
(diaminomethylene)pyrazinecarboxamide monohydrochloride, dihydrate. It
has the following structural
formula:
C H CLN O•HCL•2H O MW = 302.12
Hydrochlorothiazide is designated chemically as
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-
sulfonamide 1,1-dioxide. It has the following structural formula:
C H CLN O S MW = 297.74
It is a white, or practically white, crystalline powder which is
slightly soluble in water, but freely
soluble in sodium hydroxide solution.
Each tablet, for oral administration, contains 5 mg of amiloride
hydrochloride, USP (calculated on the
anhydrous basis) and 50 mg of hydrochlorothiazide, USP. In addition,
each tablet contains the following
inactive ingredients: croscarmellose sodium, FD&C Yellow No. 6
Aluminum Lake, lactose
monohydrate, magnesium stearate, pregelatinized starch, and sodium
lauryl sulfate.
CLINICAL PHARMACOLOGY
Amiloride hydrochloride and hydrochlorothiazide tablets provide
diuretic and antihypertensive activity
(principally due to the hydrochlorothiazide component), while acting
through the amiloride component
to prevent the excessive potassium loss that may occur in patients
receiving a thiazide diuretic. Due to
its amiloride component, the urinary excretion of magnesium is less
with amiloride and
hydrochlorothiazide than with a thiazide or loop diuretic used alone
(see PRECAUTIONS). The onset
of the diuretic action of this product is within 1 to 2 hours and this
action appears to be sustained for
approximately 24 hours.
AMILORIDE HYDROCHLORIDE
6
8
7
2
7
8
3
4
2
Amiloride hydrochloride is a potassium-conserving (antikaliuretic)
drug that possesses weak
(compare