Country: Մալայզիա
language: անգլերեն
source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Paracetamol
Noripharma Sdn. Bhd.
Paracetamol
30 Tablets; 50 Tablets; 100 Tablets; 150 Tablets; 200 Tablets; 250 Tablets; 300 Tablets; 350 Tablets; 400 Tablets; 450 Tablets; 500 Tablets; 1000 Tablets; 10 Tablets; 20 Tablets
Noripharma Sdn. Bhd.
_Consumer Medication Information Leaflet (RiMUP)_ _ _ PARANOR 500MG TABLET Paracetamol 500mg 1 | P a g e WHAT IS IN THIS LEAFLET 1. What PARANOR 500mg used for 2. How PARANOR 500mg works 3. Before you use PARANOR 500mg 4. How to use PARANOR 500mg 5. While you are using it 6. Side effects 7. Storage and Disposal of PARANOR 500mg 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of Revision. WHAT PARANOR 500MG USED FOR PARANOR 500mg Tablet is used for the relief of fever. For the relief from mild to moderate including: headache, migraine, backache, musculoskeletal pain, myalgia and neuralgia, dysmenorrhea, pain of osteoarthritis, toothache, pain after dental procedures/tooth extraction, pain after vaccination and the discomfort from colds, influenza and sore throats. HOW PARANOR 500MG WORKS PARANOR 500mg Tablet has analgesic (pain relief) and antipyretic (anti-fever) properties. BEFORE YOU USE PARANOR 500MG -_WHEN YOU MUST NOT USE IT_ Do not take PARANOR 500mg Tablet if you are allergic to Paracetamol or Acetaminophen and other ingredients. If you are not sure whether you should start taking this medicine, talk to your doctor or pharmacist. _- BEFORE YOU START TO USE IT _ This product contains Paracetamol. Do not take other Paracetamol containing medicine at the same time. Your doctor needs to know before you take PARANOR 500mg Tablet if you have kidney or liver problem. PARANOR 500mg Tablet should also be taken with care when you take other medicines that affect the liver. Discuss with your doctor or pharmacist first if you are pregnant or breastfeeding. Problems in human have not been reported when taking PARANOR 500mg Tablet during pregnancy or breastfeeding. _-TAKING OTHER MEDICINES _ Tell your doctor or pharmacist before taking PARANOR 500mg Tablet, if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop. The effects of some medicines may be affected if other medicines are used at the same tim read_full_document
Package Insert 1 PRODUCT NAME PARANOR 500mg Tablet COMPOSITION Paracetamol 500mg/tablet PRODUCT DESCRIPTION A white to off white round film coated tablet with score line one side and plain on the other side. PHARMACODYNAMICS Paracetamol is a centrally acting analgesic and antipyretic with minimal anti-inflammatory properties _ANALGESIC_-The mechanism of analgesic action has not been fully determined. Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and, to a lesser extent, through a peripheral action by blocking pain-impulse generation._ _ The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitize pain receptors to mechanical or chemical stimulation _ANTIPYRETIC_- Paracetamol act centrally on the hypothalamic heat-regulating center to produce peripheral vasodilatation resulting in increase blood flow through the skin, sweating and heat loss._ _ Paracetamol reduces fever by inhibiting the formulation and release of prostaglandins in the CNS and by inhibiting endogenous pyrogens at the hypothalamic thermoregulatory center. PHARMACOKINETICS Following oral administration paracetamol is rapidly absorbed. Paracetamol absorption takes place mainly in the small intestine and therefore the rate of absorption is depending on the rate of gastric emptying. It has been shown that drugs which delay gastric emptying also delay the absorption of paracetamol whereas metoclopramide (a drug which increases the rate of gastric emptying) accelerates absorption of the analgesic through the total amount absorbed doses not increase. The presence of food in the stomach has also been reported to reduce the rate of absorption of paracetamol. Alterations in gastric pH have no appreciable effect on paracetamol absorption. During absorption, the amount of paracetamol which is inactivated is negligible and it has been shown that paracetamol dose not affect gastric mucosal permeability an read_full_document