Country: Մալայզիա
language: անգլերեն
source: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
AMLODIPINE BESYLATE
PHARMANIAGA MANUFACTURING BERHAD
AMLODIPINE BESYLATE
10 x 10s Tablets
PHARMANIAGA MANUFACTURING BERHAD
AMNOZ TABLET Amlodipine (5mg, 10mg) 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ WHAT IS IN THIS LEAFLET 1. What Amnoz Tablet is used for 2. How Amnoz Tablet works 3. Before you use Amnoz Tablet 4. How to use Amnoz Tablet 5. While you are using it 6. Side effects 7. Storage and Disposal of Amnoz Tablet 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision 11. Serial number WHAT AMNOZ TABLET IS USED FOR Amnoz Tablet is used for the first line treatment of high blood pressure (hypertension) and can be used for the first line treatment of myocardial ischemia (decrease of blood flow in the blood vessel which leads to reduced oxygen supply in the heart) due to a certain type of chest pain called angina, whether fixed obstruction (stable angina) and / or vasospasm / vasoconstriction (Prinzmetal’s or variant angina). HOW AMNOZ TABLET WORKS Amnoz Tablet works by relaxing the blood vessels so that the blood passes through them more easily and high blood pressure is reduced. In addition, Amnoz Tablet can improve blood supply to the heart muscle and receives more oxygen, so that the chest pain is prevented. BEFORE YOU USE AMNOZ TABLET _-When you must not use it _ Do not take this medicine if you are: • Allergic or hypersensitive to dihydropyridines, amlodipine or any of the excipients. _ _ _-Before you start to use it _ Tell your doctor if you have or had any of the following conditions: • heart failure • impaired liver function If you are pregnant or intend to become pregnant, and breast-feeding, consult with your doctor or pharmacist, the possible risks and benefits of using Amnoz Tablet during pregnancy and breast-feeding. If you have not told your doctor about any of the above, tell him/her before you start taking Amnoz Tablet. _ _ _ _ _-Taking other medicines _ Please tell your doctor or pharmacist if you are taking other medicines including medicines without prescription from a pharmacy, medical hall or any other source. Some medicines and beverage might have intera read_full_document
Amlodipine was associated with increased reports of pulmonary edema despite no significant difference in the incidence of worsening heart failure compared to placebo. Calcium channel blockers, including amlodipine, should be used with caution in patients with congestive heart failure, as they may increase the risk of future cardiovascular events and mortality. _USE IN PATIENTS WITH IMPAIRED HEPATIC FUNCTION _ As with all calcium antagonists, amlodipine half-life is prolonged and AUC values are higher in patients with impaired liver function and dosage recommendations have not been established. The drug should therefore be administered with caution in these patients. Amlodipine should therefore be initiated at the lower end of the dosing range and caution should be used, both on initial treatment and when increasing the dose. Slow dose titration and careful monitoring may be required in patients with severe hepatic impairment. There are no data to support the use of amlodipine alone, during or within one month of a myocardial infarction. _EFFECTS ON ABILITY TO DRIVE AND USE MACHINES_ Amlodipine can have minor or moderate influence on the ability to drive and use machines. If patients taking amlodipine suffer from dizziness, headache, fatigue or nausea the ability to react may be impaired. Caution is recommended especially at the start of treatment. INTERACTIONS WITH OTHER MEDICAMENTS Amlodipine has been safely administered with thiazide diuretics, alpha blockers, beta blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerine, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. Amlodipine has no effect on protein binding of the drugs tested (digoxin, phenytoin, warfarin, or indomethacin). _ _ _EFFECT OF OTHER AGENTS ON AMLODIPINE_ GRAPEFRUIT JUICE: Administration of amlodipine with grapefruit or grapefruit juice is not recommended as bioavailability may be increased in some patients resulting in increased blood pressure lowering effects. SIMVAST read_full_document