Ország: Új-Zéland
Nyelv: angol
Forrás: Medsafe (Medicines Safety Authority)
Diltiazem hydrochloride 60mg;
Novartis New Zealand Ltd
Diltiazem hydrochloride 60 mg
60 mg
Film coated tablet
Active: Diltiazem hydrochloride 60mg Excipient: Colloidal silicon dioxide Hydrogenated castor oil Hypromellose Lactose monohydrate Macrogol 6000 Magnesium stearate Microcrystalline cellulose Povidone Sodium starch glycolate Stearic acid Titanium dioxide
Blister pack, PVC/PE/PVDC & aluminium foil, 100 tablets
Prescription
Prescription
Lusochimica SpA
Package - Contents - Shelf Life: Blister pack, PVC/PE/PVDC & aluminium foil - 100 tablets - 24 months from date of manufacture stored at or below 25°C
1997-07-22
NEW ZEALAND DATASHEET DILTAHEXAL _DILTIAZEM HYDROCHLORIDE PH EUR, FILM COATED TABLET, 60 MG _ PRESENTATION White, 9 mm, film-coated tablets, scored on one side. Each tablet contains diltiazem hydrochloride 60 mg. This product is not able to deliver all approved dose regimes. Do not halve tablet. USES _ACTIONS _ PHARMACOTHERAPEUTIC GROUP C08DB01 - Selective calcium channel blockers with mainly vascular effects, benzothiazepine derivatives, diltiazem. MECHANISM OF ACTION Diltiazem, a benzothiazepine type calcium antagonist, inhibits calcium ion entry into smooth muscle cells by blockade of slow calcium channels. Diltiazem acts as a potent coronary vasodilator and also has a moderate effect on peripheral circulation. Diltiazem may also prolong AV nodal conduction. PHARMACODYNAMIC EFFECTS The therapeutic effects achieved with diltiazem are believed to be related to its ability to inhibit the influx of calcium ions during membrane depolarisation of cardiac and vascular smooth muscle. Diltiazem produces its antihypertensive effects by primarily by relaxation of vascular smooth muscle and the resultant decrease in peripheral vascular resistance. The magnitude of blood pressure is related to the degree of hypertension; thus hypertensive individuals experience an antihypertensive effect, whereas there is only a modest fall in blood pressure in normotensives. In common with some other calcium antagonists, diltiazem decreases sinoatrial and atrioventricular conduction in isolated tissues and has a negative inotropic effect is isolated preparations. In the intact animal, prolongation of the atrial-His (A-H) interval can be seen at higher doses. In animal models, diltiazem interferes with the slow inward (depolarising) current in excitable tissue. It causes excitation-contraction uncoupling in various myocar Olvassa el a teljes dokumentumot