Diltahexal

국가: 뉴질랜드

언어: 영어

출처: Medsafe (Medicines Safety Authority)

유효 성분:

Diltiazem hydrochloride 60mg;  

제공처:

Novartis New Zealand Ltd

INN (International Name):

Diltiazem hydrochloride 60 mg

복용량:

60 mg

약제 형태:

Film coated tablet

구성:

Active: Diltiazem hydrochloride 60mg   Excipient: Colloidal silicon dioxide Hydrogenated castor oil Hypromellose Lactose monohydrate Macrogol 6000 Magnesium stearate Microcrystalline cellulose   Povidone Sodium starch glycolate Stearic acid Titanium dioxide

패키지 단위:

Blister pack, PVC/PE/PVDC & aluminium foil, 100 tablets

수업:

Prescription

처방전 유형:

Prescription

Manufactured by:

Lusochimica SpA

제품 요약:

Package - Contents - Shelf Life: Blister pack, PVC/PE/PVDC & aluminium foil - 100 tablets - 24 months from date of manufacture stored at or below 25°C

승인 날짜:

1997-07-22

제품 특성 요약

NEW ZEALAND DATASHEET 

DILTAHEXAL 
_DILTIAZEM HYDROCHLORIDE PH EUR, FILM COATED TABLET, 60 MG _
PRESENTATION 
White, 9 mm, film-coated tablets, scored on one side. Each
tablet contains diltiazem hydrochloride 60 
mg. This product is not able to deliver all approved dose
regimes. Do not halve tablet. 
USES 
_ACTIONS _
PHARMACOTHERAPEUTIC GROUP 
C08DB01 - Selective
calcium channel blockers with mainly vascular effects,
benzothiazepine 
derivatives, diltiazem. 
MECHANISM OF ACTION 
Diltiazem, a benzothiazepine type calcium antagonist,
inhibits calcium ion entry into smooth muscle 
cells by blockade
of slow calcium channels. Diltiazem acts as a potent coronary vasodilator
and also 
has a moderate effect on
peripheral circulation. Diltiazem may also prolong
AV nodal conduction. 
PHARMACODYNAMIC EFFECTS 
The therapeutic effects achieved with diltiazem are believed
to be related to its ability to inhibit the 
influx of calcium ions during
membrane depolarisation of cardiac and vascular smooth muscle. 
Diltiazem produces its antihypertensive effects by primarily by relaxation of vascular
smooth muscle 
and the resultant decrease in peripheral vascular
resistance. The magnitude of blood pressure is 
related to the degree of hypertension; thus hypertensive
individuals experience an antihypertensive 
effect, whereas there is only a modest fall in blood pressure
in normotensives. 
In common with some other calcium antagonists,
diltiazem decreases sinoatrial and atrioventricular 
conduction in isolated
tissues and has a negative inotropic effect is isolated
preparations. In the intact 
animal, prolongation
of the atrial-His (A-H) interval can be seen
at higher doses. 
In animal models, diltiazem interferes with the slow inward
(depolarising) current in excitable tissue. It 
causes excitation-contraction uncoupling in various myocar