Ország: Malajzia
Nyelv: angol
Forrás: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
DESOGESTREL
Vitamode Sdn.bhd
DESOGESTREL
1X28tablet Tablets
RENATA LIMITED
1 BREDICON ® 75MCG TABLET (DESOGESTREL 75 MCG) COMPOSITION: Each tablet contains: Desogestrel 75 microgram DESCRIPTION: White colored tablet, Round Flat Bevel Edge, one side contains logo “B/75” and other side plain. PHARMACODYNAMICS: This medicine is a type of hormonal contraceptive commonly known as the “mini pill” or progestogen-only pill (POP). It contains the active ingredient desogestrel , which is a synthetic progestogen, similar to the natural progestogen produced by the body. Desogestrel is thought to act as a contraceptive primarily by preventing the release of an egg from the ovary (Ovulation). It also acts by increasing the thickness of the natural mucus at the neck of the womb, making it more difficult for sperm to cross from the vagina into the womb. By preventing sperm entering the womb, successful fertilization of any eggs that are released is less likely. Desogestrel also acts to change the quality of the womb lining (endometrium). This prevents the successful implantation of any fertilized eggs onto the wall of the womb, thereby preventing pregnancy. The progesterone only-pill should be taken continuously every day, unlike combined pills, which are usually taken every day for three weeks, followed by a pill-free week. This progesterone-only pill should be taken continuously at the same time evry day for it to be effective at the preventing pregnancy. MECHANISM OF ACTION: Desogestrel is a progestogen structurally related to levonorgestrel that has been shown to reliably inhibit ovulation. After oral administration, it undergoes oxidative transformation in the intestinal mucosa and liver to form its active metabolite, 3-keto-desogestrel. 2 PHARMACOKINETICS: ABSORPTION: After oral dosing of Bredicon, Desogestrel is rapidly absorbed and converted into its biologically active metabolite etonogestrel (ENG). Under steady-state conditions, peak serum levels are reached 1.8 hrs after tablet intake and the absolute bioavailability of ENG is approximately 70%. DISTRIBUTION: ENG is 95.5-99% bound t Olvassa el a teljes dokumentumot