Ország: Egyesült Államok
Nyelv: angol
Forrás: NLM (National Library of Medicine)
HYDROCORTISONE ACETATE (UNII: 3X7931PO74) (HYDROCORTISONE - UNII:WI4X0X7BPJ)
Ferndale Laboratories, Inc.
HYDROCORTISONE ACETATE
HYDROCORTISONE ACETATE 25 mg in 1 g
PRESCRIPTION DRUG
unapproved drug other
ANALPRAM E - HYDROCORTISONE ACETATE AND PRAMOXINE HYDROCHLORIDE CREAM FERNDALE LABORATORIES, INC. _Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been_ _approved by FDA. For further information about unapproved drugs, click here._ ---------- ANALPRAM E™ CREAM 2.5% (HYDROCORTISONE ACETATE 2.5% AND PRAMOXINE HCL 1%) DESCRIPTION Analpram E™ Cream 2.5% is a topical preparation containing hydrocortisone acetate 2.5% w/w and pramoxine hydrochloride 1% w/w in a Hydrolipid™ base containing cetostearyl alcohol, ceteth 20, mineral oil, white petrolatum, propylparaben, triethanolamine lauryl sulfate, citric acid, sodium citrate, and purified water. Topical corticosteroids are anti-inflammatory and anti-pruritic agents. The structural formulat, the chemical name, molecular formulat and molecular weight for active ingredients are presented below. hydrocortisone acetate [Pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11, 17-dihydroxy-, (11-beta)-] C H O mol.wt.: 404.50 pramoxine hydrochloride [4-(3-(p-butoxyphenoxy)propyl)morpholine hydrochloride] C H NO .HCl mol. wt.: 329.87 CLINICAL PHARMACOLOGY Topical corticosteroids share anti-inflammatory, anti-pruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man. 23 32 6 17 27 3 Pramoxine hydrochloride is a topical anesthetic agent which provides temporary relief from itching and pain. It acts by stabilizing the neuronal membrane of nerve endings with which it comes into contact. PHARMACOKINETICS The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusi Olvassa el a teljes dokumentumot