ANALPRAM E hydrocortisone acetate and pramoxine hydrochloride cream

Riik: Ameerika Ühendriigid

keel: inglise

Allikas: NLM (National Library of Medicine)

Toimeaine:

HYDROCORTISONE ACETATE (UNII: 3X7931PO74) (HYDROCORTISONE - UNII:WI4X0X7BPJ)

Saadav alates:

Ferndale Laboratories, Inc.

INN (Rahvusvaheline Nimetus):

HYDROCORTISONE ACETATE

Koostis:

HYDROCORTISONE ACETATE 25 mg in 1 g

Retsepti tüüp:

PRESCRIPTION DRUG

Volitamisolek:

unapproved drug other

Toote omadused

ANALPRAM E - HYDROCORTISONE ACETATE AND PRAMOXINE HYDROCHLORIDE CREAM
FERNDALE LABORATORIES, INC.
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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ANALPRAM E™ CREAM 2.5% (HYDROCORTISONE ACETATE 2.5% AND PRAMOXINE
HCL 1%)
DESCRIPTION
Analpram E™ Cream 2.5% is a topical preparation containing
hydrocortisone acetate 2.5% w/w and
pramoxine hydrochloride 1% w/w in a Hydrolipid™ base containing
cetostearyl alcohol, ceteth 20,
mineral oil, white petrolatum, propylparaben, triethanolamine lauryl
sulfate, citric acid, sodium citrate,
and purified water.
Topical corticosteroids are anti-inflammatory and anti-pruritic
agents. The structural formulat, the
chemical name, molecular formulat and molecular weight for active
ingredients are presented below.
hydrocortisone acetate
[Pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11, 17-dihydroxy-,
(11-beta)-]
C
H O mol.wt.: 404.50
pramoxine hydrochloride
[4-(3-(p-butoxyphenoxy)propyl)morpholine hydrochloride]
C
H NO .HCl mol. wt.: 329.87
CLINICAL PHARMACOLOGY
Topical corticosteroids share anti-inflammatory, anti-pruritic and
vasoconstrictive actions.
The mechanism of anti-inflammatory activity of topical corticosteroids
is unclear. Various laboratory
methods, including vasoconstrictor assays, are used to compare and
predict potencies and/or clinical
efficacies of the topical corticosteroids. There is some evidence to
suggest that a recognizable
correlation exists between vasoconstrictor potency and therapeutic
efficacy in man.
23
32
6
17
27
3
Pramoxine hydrochloride is a topical anesthetic agent which provides
temporary relief from itching and
pain. It acts by stabilizing the neuronal membrane of nerve endings
with which it comes into contact.
PHARMACOKINETICS
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
including the vehicle, the integrity of the epidermal barrier, and the
use of occlusi