Ország: Malajzia
Nyelv: angol
Forrás: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE
HOVID BERHAD
PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE
100 Tablets; 250 Tablets (for export only) Tablets; 1000 Tablets (for export only) Tablets; 100 Tablets
HOVID BERHAD
VIACT01-var ACTIHIST DESCRIPTION ACTIHIST SYRUP Yellow transparent liquid with plum flavour. ACTIHIST TABLET Round, white uncoated tablet with shallow convex faces, scored and "HD" embossed on the same face. COMPOSITION ACTIHIST SYRUP: Each 5 ml contains: Triprolidine Hydrochloride 1.25 mg Pseudoephedrine Hydrochloride 30.00 mg ACTIHIST TABLET: Each tablet contains: Triprolidine Hydrochloride 2.50 mg Pseudoephedrine Hydrochloride 60.00 mg PHARMACODYNAMICS PSEUDOEPHEDRINE: Pseudoephedrine is a sympathomimetic agent. It is used as a bronchodilator and peripheral vasoconstrictor in preparations for the relief of nasal and bronchial congestion. It has a syimulant action on the respiratory center. It acts on alpha-adrenergic receptors in the mucosa of the respiratory tract. TRIPROLIDINE: Triprolidine is an antihistamine. It is an antagonist of the H 1 receptor effects of histamine. It acts by competing with histamine for H-1 receptor sites on effector cells. It diminishes or abolishes most of the actions of histamine mediated by the H-1 receptors. The action of histamine most readily affected is that on the involuntary muscle of the intestines, bladder, uterus and bronchioles. The antimuscarinic actions of Triprolidine provide a drying effects on the nasal mucosa. PHARMACOKINETICS ABSORPTION: Well absorbed from the gastrointestinal tract. METABOLIC REACTIONS: Both Pseudoephedrine and Triprolidine are metabolized in the liver. EXCRETION: Undergoes renal excretion. Pseudoephedrine is largely excreted unchanged in the urine together with small amounts of its hepatic metabolite while Triprolidine is mainly excreted as metabolites in the urine. Both Pseudoephedrine and Triprolidine are also excreted in breast milk. INDICATIONS This medication is used for the symptomatic relief of nasal and sinus congestion associated with common cold and allergic rhinitis. CONTRAINDICATIONS This medication should not be given to premature infants or neonates, patients undergoing anaesthesia with cyclopropane, halothane or other halogenated Olvassa el a teljes dokumentumot