ACTIHIST TABLET

País: Malasia

Idioma: inglés

Fuente: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes activos:

PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE

Disponible desde:

HOVID BERHAD

Designación común internacional (DCI):

PSEUDOEPHEDRINE HYDROCHLORIDE; TRIPROLIDINE HYDROCHLORIDE

Unidades en paquete:

100 Tablets; 250 Tablets (for export only) Tablets; 1000 Tablets (for export only) Tablets; 100 Tablets

Fabricado por:

HOVID BERHAD

Ficha técnica

VIACT01-var
ACTIHIST
DESCRIPTION
ACTIHIST SYRUP
Yellow transparent liquid with plum flavour.
ACTIHIST TABLET
Round, white uncoated tablet with shallow convex faces,
scored and "HD" embossed on the same face.
COMPOSITION
ACTIHIST SYRUP: Each 5 ml contains:
Triprolidine Hydrochloride
1.25 mg
Pseudoephedrine Hydrochloride
30.00 mg
ACTIHIST TABLET: Each tablet contains:
Triprolidine Hydrochloride
2.50 mg
Pseudoephedrine Hydrochloride
60.00 mg
PHARMACODYNAMICS
PSEUDOEPHEDRINE: Pseudoephedrine is a sympathomimetic
agent.
It
is
used
as
a
bronchodilator
and
peripheral
vasoconstrictor in preparations for the relief of nasal and
bronchial
congestion.
It
has
a
syimulant
action
on
the
respiratory center. It acts on alpha-adrenergic receptors in
the mucosa of the respiratory tract.
TRIPROLIDINE:
Triprolidine
is
an
antihistamine.
It
is
an
antagonist of the H 1 receptor effects of histamine. It acts by
competing with histamine for H-1 receptor sites on effector
cells. It diminishes or abolishes most of the actions of
histamine mediated by the H-1 receptors. The action of
histamine most readily affected is that on the involuntary
muscle of the intestines, bladder, uterus and bronchioles.
The antimuscarinic actions of Triprolidine provide a drying
effects on the nasal mucosa.
PHARMACOKINETICS
ABSORPTION: Well absorbed from the gastrointestinal tract.
METABOLIC REACTIONS: Both Pseudoephedrine and Triprolidine
are metabolized in the liver.
EXCRETION: Undergoes renal excretion. Pseudoephedrine is
largely excreted unchanged in the urine together with small
amounts of its hepatic metabolite while Triprolidine is mainly
excreted as metabolites in the urine. Both Pseudoephedrine
and Triprolidine are also excreted in breast milk.
INDICATIONS
This medication is used for the symptomatic relief of nasal
and sinus congestion associated with common cold and
allergic rhinitis.
CONTRAINDICATIONS
This medication should not be given to premature infants or
neonates,
patients
undergoing
anaesthesia
with
cyclopropane, halothane or other halogenated