Ország: Új-Zéland
Nyelv: angol
Forrás: Medsafe (Medicines Safety Authority)
Aciclovir 250mg
Novartis New Zealand Ltd
Aciclovir 250 mg
250 mg
Powder for infusion
Active: Aciclovir 250mg Excipient: Sodium hydroxide
Vial, glass, type 1/chlorobutyl rubber seal x 5, 1250 mg
Prescription
Prescription
Quimica Sintetica SA
Package - Contents - Shelf Life: Vial, glass, type 1/chlorobutyl rubber seal x 5 - 1250 mg - 3 years from date of manufacture stored at or below 25°C 12 hours reconstituted stored at 15°C to 25°C (Controlled room temp)
1999-12-10
1 NEW ZEALAND DATASHEET ACIHEXAL _ACICLOVIR, POWDER FOR INFUSION, 250 MG AND 500 MG _ PRESENTATION Acihexal is a white crystalline freeze dried powder aseptically filled into 25 ml glass vials. - Acihexal 250 mg contains sterile aciclovir 250 mg. - Acihexal 500 mg contains sterile aciclovir 500 mg. USES _ACTIONS _ PHARMACOTHERAPEUTIC GROUP J05AB01 - Direct acting antivirals, nucleosides and nucleotides excluding reverse transcriptase inhibitors, aciclovir. MECHANISM OF ACTION Aciclovir is a synthetic purine nucleoside analogue with _in vitro_ and _in vivo_ inhibitory activity against human herpes viruses, including Herpes simplex virus types 1 and 2, Varicella zoster virus (VZV), Epstein Barr virus (EBV) and Cytomegalovirus (CMV). In cell culture, aciclovir has the greatest antiviral activity against HSV-1, followed (in decreasing order of potency) by HSV-2, VZV, EBV and CMV. PHARMACODYNAMIC EFFECTS The inhibitory activity of aciclovir for HSV-1, HSV-2, VZV and EBV is highly selective. The antiviral activity of aciclovir is attributed to the phosphorylated cellular metabolite, aciclovir triphosphate. In uninfected cells, the enzyme thymidine kinase does not use aciclovir effectively as a substrate thereby limiting the conversion to aciclovir triphosphate and cellular DNA polymerase is not very sensitive to the active compound hence toxicity to mammalian host cells is low. However, thymidine kinase encoded by HSV, VZV and EBV converts aciclovir to aciclovir monophosphate, a nucleoside analogue, which is further phosphorylated to the diphosphate and finally to the triphosphate by cellular enzymes. Aciclovir triphosphate interferes with the viral DNA polymerase and inhibits viral DNA replication with resultant chain termination following i Olvassa el a teljes dokumentumot