Država: Kanada
Jezik: engleski
Izvor: Health Canada
CHLOROPROCAINE HYDROCHLORIDE
ASTRAZENECA CANADA INC
N01BA04
CHLOROPROCAINE
20MG
SOLUTION
CHLOROPROCAINE HYDROCHLORIDE 20MG
INTRACAUDAL
20ML
Ethical
LOCAL ANESTHETICS
Active ingredient group (AIG) number: 0115360001; AHFS:
CANCELLED POST MARKET
2012-05-31
COPYRIGHT 1984, 2011 ASTRAZENECA CANADA INC. Page 1 of 11 PRODUCT MONOGRAPH NESACAINE ® - CE (chloroprocaine hydrochloride injection) AstraZeneca Standard Local Anesthetic AstraZeneca Canada Inc. 1004 Middlegate Road Mississauga, Ontario L4Y 1M4 Date of Preparation: April 12, 2000 Date of Revision: April 4, 2011 Subm ission Control No: 143489 NESACAINE ® is a registered trademark of the AstraZeneca group of companies. COPYRIGHT 1984, 2011 ASTRAZENECA CANADA INC. Page 2 of 11 PRODUCT MONOGRAPH NAME OF DRUG NESACAINE ® - CE (chloroprocaine hydrochloride injection) AstraZeneca Standard THERAPEUTIC CLASSIFICATION Local Anesthetic for Infiltration and Regional Nerve Block ACTION MECHANISM OF ACTION NESACAINE (chloroprocaine hydrochloride) stabilizes the neuronal membrane and prevents the initiation and transmission of nerve impulses, thereby effecting local anesthetic action. ONSET OF ACTION The onset of action is rapid (usually within 6 to 12 minutes). The duration of anesthesia depends on the procedure and the amount used, but could last up to 60 minutes. PHARMACOKINETICS AND METABOLISM Chloroprocaine is rapidly hydrolyzed in plasma by pseudocholinesterase. This hydrolysis results in the formation of β-diethylaminoethanol and 2-chloro-4-aminobenzoic acid which inhibits the action of sulfonamides. See PRECAUTIONS. Solutions of NESACAINE do not injure nervous tissue and are not irritating to other tissues in the recommended concentrations. INDICATIONS AND CLINICAL USE NESACAINE (chloroprocaine hydrochloride) is indicated for the production of local anesthesia by infiltration and regional nerve block, including caudal and epidural blocks. Any unused portion should be discarded. NESACAINE should not be used for spinal anesthesia. COPYRIGHT 1984, 2011 ASTRAZENECA CANADA INC. Page 3 of 11 CONTRAINDICATIONS NESACAINE (chloroprocaine hydrochloride) is contraindicated in patients hypersensitive (allergic) to drugs of the PABA ester group. Although central nervous system disease is generally considered a contraindication Pročitajte cijeli dokument