NESACAINE CE 2% INJ 20MG/ML SOLUTION

País: Canadá

Idioma: inglés

Fuente: Health Canada

Ingredientes activos:

CHLOROPROCAINE HYDROCHLORIDE

Disponible desde:

ASTRAZENECA CANADA INC

Código ATC:

N01BA04

Designación común internacional (DCI):

CHLOROPROCAINE

Dosis:

20MG

formulario farmacéutico:

SOLUTION

Composición:

CHLOROPROCAINE HYDROCHLORIDE 20MG

Vía de administración:

INTRACAUDAL

Unidades en paquete:

20ML

tipo de receta:

Ethical

Área terapéutica:

LOCAL ANESTHETICS

Resumen del producto:

Active ingredient group (AIG) number: 0115360001; AHFS:

Estado de Autorización:

CANCELLED POST MARKET

Fecha de autorización:

2012-05-31

Ficha técnica

COPYRIGHT 1984, 2011 ASTRAZENECA CANADA INC.
Page 1 of 11
PRODUCT MONOGRAPH
NESACAINE
® - CE
(chloroprocaine hydrochloride injection)
AstraZeneca Standard
Local Anesthetic
AstraZeneca Canada Inc.
1004 Middlegate Road
Mississauga, Ontario
L4Y 1M4
Date of Preparation: April 12, 2000
Date of Revision:
April 4, 2011
Subm
ission Control No: 143489
NESACAINE
®
is a registered trademark of the AstraZeneca group of companies.
COPYRIGHT 1984, 2011 ASTRAZENECA CANADA INC.
Page 2 of 11
PRODUCT MONOGRAPH
NAME OF DRUG
NESACAINE
®
- CE
(chloroprocaine hydrochloride injection)
AstraZeneca Standard
THERAPEUTIC CLASSIFICATION
Local Anesthetic for Infiltration and Regional Nerve Block
ACTION
MECHANISM OF ACTION
NESACAINE (chloroprocaine hydrochloride) stabilizes the neuronal
membrane and prevents
the initiation and transmission of nerve impulses, thereby effecting
local anesthetic action.
ONSET OF ACTION
The onset of action is rapid (usually within 6 to 12 minutes). The
duration of anesthesia
depends on the procedure and the amount used, but could last up to 60
minutes.
PHARMACOKINETICS AND METABOLISM
Chloroprocaine is rapidly hydrolyzed in plasma by
pseudocholinesterase. This hydrolysis
results in the formation of β-diethylaminoethanol and
2-chloro-4-aminobenzoic acid which
inhibits the action of sulfonamides. See PRECAUTIONS.
Solutions of NESACAINE do not injure nervous tissue and are not
irritating to other tissues in
the recommended concentrations.
INDICATIONS AND CLINICAL USE
NESACAINE (chloroprocaine hydrochloride) is indicated for the
production of local
anesthesia by infiltration and regional nerve block, including caudal
and epidural blocks. Any
unused portion should be discarded. NESACAINE should not be used for
spinal anesthesia.
COPYRIGHT 1984, 2011 ASTRAZENECA CANADA INC.
Page 3 of 11
CONTRAINDICATIONS
NESACAINE (chloroprocaine hydrochloride) is contraindicated in
patients hypersensitive
(allergic) to drugs of the PABA ester group.
Although central nervous system disease is generally considered a
contraindication