Hyzaar

Država: Novi Zeland

Jezik: engleski

Izvor: Medsafe (Medicines Safety Authority)

Aktivni sastojci:

Hydrochlorothiazide 12.5mg;  ;  ; Losartan potassium 50mg;  

Dostupno od:

Merck Sharp & Dohme (New Zealand) Limited

INN (International ime):

Hydrochlorothiazide 12.5 mg

Doziranje:

50mg/12.5mg

Farmaceutski oblik:

Film coated tablet

Sastav:

Active: Hydrochlorothiazide 12.5mg     Losartan potassium 50mg   Excipient: Carnauba wax Hyprolose Hypromellose Lactose monohydrate Magnesium stearate Microcrystalline cellulose Quinoline yellow Starch Titanium dioxide

Jedinice u paketu:

Calendar pack, 15 foil blister, professional sample pack, 15 tablets

Razred:

Prescription

Tip recepta:

Prescription

Proizveden od:

Plantex Ltd

Terapijske indikacije:

Hypertension HYZAAR is indicated for the treatment of hypertension, for patients in whom combination therapy is appropriate. Reduction in the Risk of Cardiovascular Morbidity and Mortality in Hypertensive Patients with Left Ventricular Hypertrophy HYZAAR is a combination of losartan (COZAAR) and hydrochlorothiazide. In patients with hypertension and left ventricular hypertrophy, losartan, often in combination with hydrochlorothiazide, reduces the risk of cardiovascular morbidity and mortality as measured by the combined incidence of cardiovascular death, stroke, and myocardial infarction in hypertensive patients with left ventricular hypertrophy.

Proizvod sažetak:

Package - Contents - Shelf Life: Calendar pack, foil blister, professional sample pack - 15 tablets - 36 months from date of manufacture stored at or below 30°C - Calendar pack, foil blisters - 30 tablets - 36 months from date of manufacture stored at or below 30°C

Datum autorizacije:

1994-02-23

Uputa o lijeku

1
HYZAAR
®
_losartan potassium and hydrochlorothiazide _
50/12.5 mg tablet
WHAT IS IN THIS LEAFLET
This leaflet answers some common questions about HYZAAR. It does not
contain all the
available information. It does not take the place of talking to your
doctor and pharmacist.
All medicines have risks and benefits. Your doctor has weighed the
risks of you taking
HYZAAR against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor
or pharmacist.
Keep this leaflet with the medicine. You may need to read it again.
WHAT HYZAAR IS USED FOR
HYZAAR lowers high blood pressure, which doctors call hypertension. It
may be used
alone or in combination with other medicines. In patients with high
blood pressure and a
thickening of the left ventricle, losartan, often in combination with
hydrochlorothiazide,
reduces the risk of stroke and heart attack and helps patients live
longer.
Everyone has blood pressure. This pressure helps get your blood all
around your body.
Your blood pressure may be different at different times of the day,
depending on how busy
or worried you are. You have hypertension (high blood pressure) when
your blood
pressure stays higher than is needed, even when you are calm and
relaxed.
There are usually no symptoms of hypertension. The only way of knowing
that you have
hypertension is to have your blood pressure checked on a regular
basis. If high blood
pressure is not treated it can lead to serious health problems. You
may feel fine and have
no symptoms, but eventually hypertension can cause stroke, heart
disease or kidney
failure. Over time, high blood pressure causes the heart to work
harder, which can lead to
a thickening of the left ventricle. A thickening of the left ventricle
of the heart is associated
with an increased chance of experiencing a stroke.
Your doctor may have prescribed HYZAAR for another reason. Ask your
doctor if you
have any questions about why HYZAAR has been prescribed for you.
HYZAAR is not addictive.
HOW DOES HYZAAR WORK

Svojstava lijeka

Page 1 of 17
NEW ZEALAND DATA SHEET
1 PRODUCT NAME
HYZAAR
®
50/12.5 mg tablet
2 QUALITATIVE AND QUANTITATIVE COMPOSITION
losartan potassium 50 mg
hydrochlorothiazide 12.5 mg
For the full list of excipients, see section 6.1.
3 PHARMACEUTICAL FORM
A yellow oval shaped film-coated tablet with 717 on one side and plain
on the other.
Dimensions 11.21 mm x 6.05 mm.
4 CLINICAL PARTICULARS
4.1
THERAPEUTIC INDICATIONS
Hypertension
HYZAAR is indicated for the treatment of hypertension, for patients in
whom combination
therapy is appropriate.
Reduction in the Risk of Cardiovascular Morbidity and Mortality in
Hypertensive Patients with
Left Ventricular Hypertrophy
HYZAAR is a combination of losartan and hydrochlorothiazide. In
patients with hypertension
and left ventricular hypertrophy, losartan, often in combination with
hydrochlorothiazide,
reduces the risk of cardiovascular morbidity and mortality as measured
by the combined
incidence of cardiovascular death, stroke, and myocardial infarction
in hypertensive patients
with left ventricular hypertrophy (see Section 4.4, _Race_).
4.2
DOSE AND METHOD OF ADMINISTRATION
DOSE
Hypertension
The usual starting and maintenance dose of HYZAAR is one tablet once
daily. For patients
who do not respond adequately to HYZAAR, the dosage may be increased
to two tablets once
daily. The maximum dose is two tablets once daily. In general the
antihypertensive effect is
attained within three weeks after initiation of therapy.
HYZAAR should not be initiated in patients who are intravascularly
volume-depleted (e.g.
those treated with high-dose diuretics).
Page 2 of 17
Reduction in the Risk of Cardiovascular Morbidity and Mortality in
Hypertensive Patients with
Left Ventricular Hypertrophy
The usual starting dose is 50 mg of losartan once daily. If goal blood
pressure is not reached
with losartan 50 mg, therapy should be titrated using a combination of
losartan and a low dose
of hydrochlorothiazide (12.5 mg*) and, if needed, the dose should then
be increased to
losartan 100 mg and hydrochlorothia