Država: Malezija
Jezik: engleski
Izvor: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
ENROFLOXACIN
ELANCO MALAYSIA SDN BHD
ENROFLOXACIN
50.00 mcg/mL
KVP Pharma + Veterinar Produkte GmbH
M0004436 Mock-Up / 500668MB 148 x 210 mm 8 pt MK 2 23.03.2021 Schwarz Kontur For Dogs and Cats 50 MG TABLETS Antimicrobial M0004436 PRODUCT DESCRIPTION BAYTRIL ® FLAVOUR TABLETS 50 MG is a light brown to brown, slightly marbled, round and voulted tablet. Each tablet contains 50 mg of enrofloxacin. PHARMACODYNAMICS Enrofloxacin is bactericidal in action with activity against Gram positive and Gram negative bacteria and mycoplasmas. The mechanism of action of the quinolones is unique among antimicrobials – they act primarily to inhibit bacterial DNA gyrase, an enzyme responsible for controlling the super - coiling of bacterial DNA during replication. Resealing of the double standard helix is inhibited resulting in irreversible degradation of the chromosomal DNA. The fluoroquinolones also possess activity against bacteria in the stationary phase by an alteration of the permeability of the outer membrane phospholipid cell wall. PHARMACOKINETICS The pharmacokinetics of enrofloxacin in dogs and cats are such that oral and parenteral administra - tion leads to similar serum levels. Enrofloxacin possesses a high distribution volume. Tissue levels 2 – 3 times higher than that found in the serum, have been demonstrated in laboratory animals and target species. Organs in which high levels can be expected are the lungs, liver, kidney, skin, bone and lymphatic system. Enrofloxacin also distributes into the cerebrospinal fluid, the aqueous humour and the foetus in pregnant animals. INDICATION The product is for use in cats and dogs in the treatment of bacterial infections of the alimentary, respiratory and urogenital tracts, skin, secondary wound infections and otitis externa where clinical experience, supported where possible by sensi - tivity testing of the causal organism, indicates enrofloxacin as the drug of choice. RECOMMENDED DOSAGE 1 tablet Baytril Flavour Tablets 50 mg per 10 kg bodyweight MODE OF ADMINISTRATION The dosage rate of enrofloxacin is 5 mg/kg given orally once daily or as a divided dose twice daily fo Pročitajte cijeli dokument