देश: मलेशिया
भाषा: अंग्रेज़ी
स्रोत: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Doxycycline Hyclate
RANGE PHARMA SDN. BHD.
Doxycycline Hyclate
100 gm; 25 kg; 200 gm; 500 gm; 1 kg
RANGE PHARMA SDN. BHD.
VIBRASURE 500MG/G POWDER DESCRIPTION AND COMPOSITION VIBRASURE 500MG/G POWDER is a yellow powder. Each gram contains 500mg Doxycycline hyclate as its active ingredient. PHARMACODYNAMICS Doxycycline is a broad-spectrum antibiotic. It inhibits bacterial protein synthesis intracellularly by binding on the 30-S ribosome subunits. This interferes with binding of aminoacetyl-tRNA to the acceptor site on the mRNA ribosome complex and prevents coupling of amino acids to the elongating peptide chains. Doxycycline inhibits bacteria and Mycoplasma. Four resistance mechanisms acquired by microorganisms against tetracyclines in general have been reported: Decreased accumulation of tetracyclines (decreased permeability of the bacterial cell wall and active efflux), protein protection of the bacterial ribosome, enzymatic inactivation of the antibiotic and rRNA mutations (preventing the tetracycline binding to ribosome). Tetracycline resistance is usually acquired by means of plasmids or other mobile elements (e.g. conjugative transposons). Cross resistance between tetracyclines has also been described. Due to the greater liposolubility and greater facility to pass through cell membranes (in comparison to tetracycline), doxycycline retains a certain degree of efficacy against microorganisms with acquired resistance to tetracycline. PHARMACOKINETICS Doxycycline is quickly and almost completely absorbed from the intestine. The presence of food in the intestine has no effect on the actual absorption of doxycycline. The distribution of doxycycline and penetration of doxycycline throughout most body tissues is good. Following absorption, tetracyclines are hardly metabolized. In contrast to the other tetracyclines, doxycycline is mainly excreted via the faeces. Calves: After a dosage of 10mg per kg body weight per day during 5 days, an elimination halftime varying between 15 and 28 hours was found. The doxycycline plasma level reached an average of 2.2 to 2.5μg/ml. Pigs: In pigs, no accumulation of doxycycline in plasma was found aft पूरा दस्तावेज़ पढ़ें