VIBRASURE 500MGG POWDER

Country: Malasja

Lingwa: Ingliż

Sors: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredjent attiv:

Doxycycline Hyclate

Disponibbli minn:

RANGE PHARMA SDN. BHD.

INN (Isem Internazzjonali):

Doxycycline Hyclate

Unitajiet fil-pakkett:

100 gm; 25 kg; 200 gm; 500 gm; 1 kg

Manifatturat minn:

RANGE PHARMA SDN. BHD.

Karatteristiċi tal-prodott

VIBRASURE 500MG/G POWDER
DESCRIPTION AND COMPOSITION
VIBRASURE 500MG/G POWDER is a yellow powder. Each gram contains 500mg
Doxycycline
hyclate as its active ingredient.
PHARMACODYNAMICS
Doxycycline is a broad-spectrum antibiotic. It inhibits bacterial
protein synthesis intracellularly by
binding on the 30-S ribosome subunits. This interferes with binding of
aminoacetyl-tRNA to the
acceptor site on the mRNA ribosome complex and prevents coupling of
amino acids to the
elongating peptide chains.
Doxycycline
inhibits
bacteria
and Mycoplasma.
Four
resistance mechanisms
acquired
by
microorganisms against tetracyclines in general have been reported:
Decreased accumulation
of tetracyclines (decreased permeability of the bacterial cell wall
and active efflux), protein
protection of the bacterial ribosome, enzymatic inactivation of the
antibiotic and rRNA mutations
(preventing the tetracycline binding to ribosome). Tetracycline
resistance is usually acquired by
means of plasmids or other mobile elements (e.g. conjugative
transposons). Cross resistance
between tetracyclines has also been described. Due to the greater
liposolubility and greater
facility to pass through cell membranes (in comparison to
tetracycline), doxycycline retains a
certain degree of efficacy against microorganisms with acquired
resistance to tetracycline.
PHARMACOKINETICS
Doxycycline is quickly and almost completely absorbed from the
intestine. The presence of food
in the intestine has no effect on the actual absorption of
doxycycline. The distribution of
doxycycline and penetration of doxycycline throughout most body
tissues is good. Following
absorption,
tetracyclines
are
hardly
metabolized.
In
contrast
to
the
other
tetracyclines,
doxycycline is mainly excreted via the faeces.
Calves:
After a dosage of 10mg per kg body weight per day during 5 days, an
elimination halftime
varying between 15 and 28 hours was found. The doxycycline plasma
level reached an average
of 2.2 to 2.5μg/ml.
Pigs:
In pigs, no accumulation of doxycycline in plasma was found aft