देश: ऑस्ट्रेलिया
भाषा: अंग्रेज़ी
स्रोत: Department of Health (Therapeutic Goods Administration)
Cisatracurium besylate
Aspen Pharmacare Australia Pty Ltd
Medicine Registered
1 NIMBEX ® INJECTION _CISATRACURIUM BESYLATE_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about NIMBEX. It does not contain all of the available information. Reading this leaflet does not take the place of talking to your doctor or pharmacist. Taking any medicine involves some risk. It is possible that all risks associated with this medicine might not have been detected, despite proper testing. Only your doctor or pharmacist is able to weigh up all of the relevant facts, and you should consult them if you have any queries. IF YOU HAVE ANY CONCERNS ABOUT THE USE OF NIMBEX ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS INFORMATION. You may want to read it again. This leaflet provides information about NIMBEX. The statements that are made in this leaflet cannot be applied to any other medicine, even those that are similar or appear to contain the same ingredients. WHAT NIMBEX IS USED FOR NIMBEX is used to relax the body’s muscles. NIMBEX will normally be given to you when you are in surgery, or during other medical procedures. NIMBEX is only used in conjunction with an anaesthetic, so you will be asleep during the procedure. IF YOU HAVE ANY QUESTIONS ABOUT WHY NIMBEX IS USED ASK YOUR DOCTOR. _HOW DOES NIMBEX WORK?_ Cisatracurium besylate (the active ingredient in NIMBEX) belongs to a group of medicines called “neuromuscular blockers”. NIMBEX works by blocking the effects of one of the body’s chemical messengers called acetylcholine. Acetylcholin पूरा दस्तावेज़ पढ़ें
1 PRODUCT INFORMATION NIMBEX ® INJECTION NAME OF THE MEDICINE: Cisatracurium besylate The chemical name of cisatracurium besylate is (1R,1’R,2R,2’R,)-2,2’-(3,11-dioxo-4,10- dioxatridecamethylene) bis (1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1- veratrylisoquinolinium) dibenzenesulfonate. The molecular formula of cisatracurium besylate is C 65 H 82 N 2 O 18 S 2 and it has a molecular weight of 1243.5. The structural formula is given below: CAS NUMBER: 96946-42-8 DESCRIPTION: Cisatracurium besylate is a white to pale yellow powder. Nimbex Injection is supplied in two strengths, either 2 mg or 5 mg of cisatracurium besylate per mL. Nimbex Injection also contains Water for Injections and benzenesulfonic acid. Nimbex Injection does not contain any preservative and is intended for single patient use only. PHARMACOLOGY: PHARMACODYNAMICS Cisatracurium besylate, a stereoisomer of atracurium, is an intermediate duration, non-depolarising benzylisoquinolinium skeletal muscle relaxant. Cisatracurium besylate binds to cholinergic receptors on the motor end-plate to antagonise the action of acetylcholine, resulting in a competitive block of neuromuscular transmission. This action is readily reversed by anticholinesterase agents such as neostigmine. The ED 95 (dose required to produce 95% depression of the twitch response of the adductor pollicis muscle to stimulation of the ulnar nerve) of cisatracurium besylate is estimated to be 0.05 mg/kg bodyweight during opioid anaesthesia (thiopentone, fentanyl, midazolam). The recommended intubation dose for cisatracurium in पूरा दस्तावेज़ पढ़ें