देश: कनाडा
भाषा: अंग्रेज़ी
स्रोत: Health Canada
ACETYLSALICYLIC ACID
PHARMASCIENCE INC
B01AC06
ACETYLSALICYLIC ACID
81MG
TABLET (CHEWABLE)
ACETYLSALICYLIC ACID 81MG
ORAL
30/120/150/180
OTC
SALICYLATES
Active ingredient group (AIG) number: 0101169013; AHFS:
CANCELLED POST MARKET
2020-01-10
PRODUCT MONOGRAPH CHEWABLE DAILY LOW DOSE ASA (Acetylsalicylic acid chewable tablets, USP) 81 mg Analgesic, anti-inflammatory, antipyretic and platelet aggregation inhibitor PHARMASCIENCE INC. Date of Preparation: 6111 Royalmount Ave, Suite # 100 April 5, 2012 Montreal, Quebec H4P2T4 Submission Control No: 154310 PRODUCT MONOGRAPH CHEWABLE DAILY LOW DOSE ASA (Acetylsalicylic acid chewable tablets, USP) 81 mg THERAPEUTIC OR PHARMACOLOGICAL CLASSIFICATION Analgesic, anti-inflammatory, anti-pyretic and platelet aggregation inhibitor. ACTION AND CLINICAL PHARMACOLOGY ASA interferes with the production of prostaglandins in various organs and tissues through acetylation of the enzyme cyclo-oxygenase. Prostaglandins are themselves powerful irritants and produce headaches and pain on injection in man. Prostaglandins also appear to sensitize pain receptors to other noxious substances such as histamine and bradykinin. By preventing the synthesis and release of prostaglandins in inflammation, ASA may avert the sensitization of pain receptors. The antipyretic activity of ASA is due to its ability to interfere with the production of prostaglandin E 1 in the brain. Prostaglandin E 1 is one of the most powerful pyretic agents known. The inhibition of platelet aggregation by ASA is due to its ability to interfere with the production of thromboxane A 2 within the platelet. Thromboxane A 2 is largely responsible for the aggregating properties of platelets. 3 INDICATIONS AND CLINICAL USE Acetylsalicylic acid (ASA) is indicated for the relief of pain, fever and inflammation of a variety of conditions such as influenza, common cold, low back and neck pain, dysmenorrhea, headache, toothache, sprains and strains, fractures, myositis, neuralgia, synovitis, arthritis, bursitis, burns, injuries, following surgical and dental procedures. CHEWABLE DAILY LOW DOSE ASA 81 mg are also indicated for the following uses, based on its platelet aggregation inhibitory properties: -For reducing the risk of morbidity and death in patients with unstable पूरा दस्तावेज़ पढ़ें