देश: ऑस्ट्रेलिया
भाषा: अंग्रेज़ी
स्रोत: Department of Health (Therapeutic Goods Administration)
Adenosine
Sanofi-Aventis Australia Pty Ltd
Medicine Registered
ADENOSCAN ® _Adenosine_ CONSUMER MEDICINE INFORMATION (CMI) WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Adenoscan. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you being given this medicine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT BEING GIVEN THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. WHAT ADENOSCAN IS USED FOR Adenoscan is used as an aid to doctors, to understand how your heart is working. Adenoscan is used during radionuclide imaging of your heart. Adenoscan is given to you before the radionuclide (the agent which allows them to see your heart). Adenoscan works by opening up your heart's blood vessels to allow blood to flow more freely and can then be seen more clearly by doctors. Adenoscan is only given in hospitals. It is given to you as an injection. Your doctor, however, may prescribe Adenoscan for another purpose. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY IT HAS BEEN PRESCRIBED FOR YOU. This medicine is only available with a doctor's prescription. This medicine is not addictive. BEFORE YOU ARE GIVEN IT _WHEN YOU MUST NOT BE GIVEN_ _IT_ DO NOT RECEIVE ADENOSCAN IF YOU HAVE: • asthma or any other lung disease • recently had a heart transplant • some other problems with your heart or heart rhythm • severe low blood pressure DO NOT RECEIVE ADENOSCAN IF YOU ARE ALLERGIC TO IT OR ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET. Some symptoms of an allergic reaction include skin rash, itching, shortness of breath or swelling of the face, lips or tongue, which may cause difficulty in swallowing or breathing. _BEFORE YOU ARE GIVEN IT_ TELL YOUR DOCTOR IF YOU HAVE ALLERGIES TO: - ANY OF THE INGREDIENTS LISTED AT THE END OF THIS LEAFLET - ANY OTHER MEDICINES INCLUDING • theophylline or aminophylline • dipyridamole • carbamazepine - ANY OTHER SUB पूरा दस्तावेज़ पढ़ें
Adenoscan PIv3.0 CCDSv7 21 Jun 13 Page 1 PRODUCT INFORMATION ADENOSCAN ® NAME OF THE MEDICINE Adenoscan (adenosine) Adenosine is designated chemically as 6-amino-9- -D-ribofuranosyl-9H-purine and has the following chemical structure: Adenosine is a white crystalline powder slightly soluble in water with a molecular weight of 267.2 and an empirical formula of C 10 H 13 N 5 O 4 . DESCRIPTION Adenoscan is a sterile solution for intravenous infusion, provided in clear glass vials. Each vial contains 30 mg of adenosine in 10 mL of a 0.9% w/v solution of sodium chloride in sterile water for injections. PHARMACOLOGY MECHANISM OF ACTION Adenosine is a potent vasodilator in most vascular beds, except in renal afferent arterioles and hepatic veins where it produces vasoconstriction. Adenosine is thought to exert its pharmacological effects through activation of purine receptors (cell-surface A1 and A2 adenosine receptors). Although the exact mechanism by which adenosine receptor activation relaxes vascular smooth muscle is not known, there is evidence to support both inhibition of the slow inward calcium current reducing calcium uptake and activation of adenylate cyclase through A2 receptors in smooth muscle cells. Adenosine may also lessen vascular tone by modulating sympathetic neurotransmission. The intracellular uptake of adenosine is mediated by a specific transmembrane nucleoside transport system. Once inside the cell, adenosine is rapidly phosphorylated by adenosine kinase to adenosine monophosphate, or deaminated by adenosine deaminase to inosine. पूरा दस्तावेज़ पढ़ें