Adenoscan

País: Austràlia

Idioma: anglès

Font: Department of Health (Therapeutic Goods Administration)

ingredients actius:

Adenosine

Disponible des:

Sanofi-Aventis Australia Pty Ltd

clase:

Medicine Registered

Informació per a l'usuari

ADENOSCAN
®

_Adenosine_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Adenoscan.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you being given this
medicine against the benefits they
expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
BEING GIVEN THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
WHAT ADENOSCAN IS
USED FOR
Adenoscan is used as an aid to
doctors, to understand how your
heart is working. Adenoscan is used
during radionuclide imaging of your
heart.
Adenoscan is given to you before the
radionuclide (the agent which allows
them to see your heart).
Adenoscan works by opening up
your heart's blood vessels to allow
blood to flow more freely and can
then be seen more clearly by doctors.
Adenoscan is only given in hospitals.
It is given to you as an injection.
Your doctor, however, may prescribe
Adenoscan for another purpose.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY IT HAS BEEN
PRESCRIBED FOR YOU.
This medicine is only available with
a doctor's prescription.
This medicine is not addictive.
BEFORE YOU ARE GIVEN IT
_WHEN YOU MUST NOT BE GIVEN_
_IT_
DO NOT RECEIVE ADENOSCAN IF YOU
HAVE:
•
asthma or any other lung disease
•
recently had a heart transplant
•
some other problems with your
heart or heart rhythm
•
severe low blood pressure
DO NOT RECEIVE ADENOSCAN IF YOU
ARE ALLERGIC TO IT OR ANY OF THE
INGREDIENTS LISTED AT THE END OF THIS
LEAFLET.
Some symptoms of an allergic
reaction include skin rash, itching,
shortness of breath or swelling of the
face, lips or tongue, which may cause
difficulty in swallowing or breathing.
_BEFORE YOU ARE GIVEN IT_
TELL YOUR DOCTOR IF YOU HAVE
ALLERGIES TO:
-
ANY OF THE INGREDIENTS LISTED AT
THE END OF THIS LEAFLET
-
ANY OTHER MEDICINES INCLUDING
•
theophylline or aminophylline
•
dipyridamole
•
carbamazepine
-
ANY OTHER SUB

Fitxa tècnica

Adenoscan PIv3.0 CCDSv7 21 Jun 13 
Page 1  

PRODUCT INFORMATION 
ADENOSCAN
®

NAME OF THE MEDICINE 
Adenoscan (adenosine) 
Adenosine  is  designated  chemically  as  6-amino-9-

-D-ribofuranosyl-9H-purine  and  has  the 
following chemical structure: 

Adenosine is a white crystalline powder slightly soluble in water with a molecular weight of 267.2 
and an empirical formula of C
10
H
13
N
5
O
4
.   
DESCRIPTION 
Adenoscan  is  a  sterile  solution  for  intravenous  infusion,  provided  in  clear  glass  vials.  Each  vial 
contains 30 mg of adenosine in 10 mL of a 0.9% w/v solution
of sodium chloride in sterile water for 
injections. 
PHARMACOLOGY 
MECHANISM OF ACTION 
Adenosine  is  a  potent  vasodilator  in  most  vascular  beds,  except  in  renal  afferent  arterioles  and 
hepatic  veins  where  it  produces  vasoconstriction.    Adenosine  is  thought  to  exert  its 
pharmacological effects through activation of purine receptors (cell-surface A1 and A2 adenosine 
receptors). 
Although  the  exact  mechanism  by  which  adenosine  receptor  activation  relaxes  vascular  smooth 
muscle is not known, there is evidence to support both
inhibition of the slow inward calcium current 
reducing  calcium  uptake  and  activation  of  adenylate  cyclase  through  A2  receptors  in  smooth 
muscle  cells.      Adenosine  may  also  lessen  vascular  tone  by  modulating  sympathetic 
neurotransmission.    The  intracellular  uptake  of  adenosine  is  mediated  by  a  specific 
transmembrane  nucleoside  transport  system.    Once  inside  the  cell,  adenosine  is  rapidly 
phosphorylated by adenosine kinase to adenosine monophosphate, or  deaminated by adenosine 
deaminase to inosine.�