ZINC- zinc chloride injection, solution

מדינה: ארצות הברית

שפה: אנגלית

מקור: NLM (National Library of Medicine)

מרכיב פעיל:

ZINC CHLORIDE (UNII: 86Q357L16B) (ZINC CATION - UNII:13S1S8SF37)

זמין מ:

Hospira, Inc.

INN (שם בינלאומי):

ZINC CHLORIDE

הרכב:

ZINC CATION 1 mg in 1 mL

מסלול נתינה (של תרופות):

INTRAVENOUS

סוג מרשם:

PRESCRIPTION DRUG

סממני תרפויטית:

Zinc 1 mg/mL (Zinc Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition. Administration helps to maintain zinc serum levels and to prevent depletion of endogenous stores, and subsequent deficiency symptoms. None known. None known.

leaflet_short:

Zinc 1 mg/mL (Zinc Chloride Injection, USP) is supplied in 10 mL single-dose Plastic Vials. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Distributed by Hospira, Inc., Lake Forest, IL 60045 USA LAB-1069-2.0 Revised: 7/2020

מצב אישור:

New Drug Application

מאפייני מוצר

ZINC- ZINC CHLORIDE INJECTION, SOLUTION
HOSPIRA, INC.
----------
ZINC
1 MG/ML
ZINC CHLORIDE INJECTION, USP
FOR I.V. USE ONLY AFTER DILUTION
PLASTIC VIAL
RX ONLY
DESCRIPTION
Zinc 1 mg/mL (Zinc Chloride Injection, USP) is a sterile, nonpyrogenic
solution intended
for use as an additive to intravenous solutions for total parenteral
nutrition. Each mL of
solution contains 2.09 mg zinc chloride and 9 mg sodium chloride. The
solution contains
no bacteriostat, antimicrobial agent or added buffer. The pH is 2.0
(1.5 to 2.5); product
may contain hydrochloric acid and sodium hydroxide for pH adjustment.
The osmolarity
is 0.354 mOsmoL/mL (calc.).
Zinc Chloride, USP is chemically designated ZnCl
, a white crystalline compound freely
soluble in water.
Sodium Chloride, USP is chemically designated NaCl, a white
crystalline compound freely
soluble in water.
The semi-rigid vial is fabricated from a specially formulated
polyolefin. It is a copolymer of
ethylene and propylene. The safety of the plastic has been confirmed
by tests in animals
according to USP biological standards for plastic containers. The
small amount of water
vapor that can pass through the plastic container wall will not
significantly alter the drug
concentration.
CLINICAL PHARMACOLOGY
Zinc is an essential nutritional requirement and serves as a cofactor
for more than 70
different enzymes including carbonic anhydrase, alkaline phosphatase,
lactic
dehydrogenase, and both RNA and DNA polymerase. Zinc facilitates wound
healing,
helps maintain normal growth rates, normal skin hydration, and the
senses of taste and
smell.
Zinc resides in muscle, bone, skin, kidney, liver, pancreas, retina,
prostate and
particularly in the red and white blood cells. Zinc binds to plasma
albumin, α -
macroglobulin, and some plasma amino acids including histidine,
cysteine, threonine,
glycine, and asparagine. Ingested zinc is excreted mainly in the stool
(approximately
90%), and to a lesser extent in the urine and in perspiration.
Providing zinc helps prevent development of deficiency