VASOPRESSIN injection, solution

מדינה: ארצות הברית

שפה: אנגלית

מקור: NLM (National Library of Medicine)

מרכיב פעיל:

VASOPRESSIN (UNII: Y87Y826H08) (VASOPRESSIN - UNII:Y87Y826H08)

זמין מ:

Feneral Injectables & Vaccines, Inc

INN (שם בינלאומי):

VASOPRESSIN

הרכב:

VASOPRESSIN 20 [USP'U] in 1 mL

מסלול נתינה (של תרופות):

INTRAMUSCULAR

סוג מרשם:

PRESCRIPTION DRUG

סממני תרפויטית:

Vasopressin Injection, USP is indicated for prevention and treatment of postoperative abdominal distention, in abdominal roentgenography to dispel interfering gas shadows and in diabetes insipidus. Anaphylaxis or hypersensitivity to the drug or its components.

leaflet_short:

Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Do not freeze. Vial stoppers do not contain natural rubber latex. APP APP PHARMACEUTICALS, LLC Schaumburg, IL 60173 45875E Revised:  March 2010

מצב אישור:

unapproved drug other

מאפייני מוצר

VASOPRESSIN- VASOPRESSIN INJECTION, SOLUTION
FENERAL INJECTABLES & VACCINES, INC
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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VASOPRESSIN INJECTION, USP (SYNTHETIC)
DESCRIPTION:
Vasopressin Injection, USP is a sterile solution of synthetic
vasopressin of the posterior pituitary gland
for intramuscular (IM) or subcutaneous use. It is substantially free
from the oxytocic principle and is
standardized to contain 20 pressor units/mL. The chemical name is
Vasopressin, 8-L-arginine and has
the following structural formula:
Each mL contains: 20 USP Vasopressin Units, chlorobutanol (anhydrous)
5 mg as preservative; Water
for Injection q.s. Glacial acetic acid and/or sodium hydroxide may
have been added for pH adjustment
(2.4-4.5).
CLINICAL PHARMACOLOGY:
The antidiuretic action of vasopressin is ascribed to increasing
reabsorption of water by the renal
tubules.
Vasopressin can cause contraction of smooth muscle of the
gastrointestinal tract and of all parts of the
vascular bed, especially the capillaries, small arterioles and venules
with less effect on the smooth
musculature of the large veins. The direct effect on the contractile
elements is neither antagonized by
adrenergic blocking agents nor prevented by vascular denervation.
Following subcutaneous or intramuscular administration of vasopressin
injection, the duration of
antidiuretic activity is variable but effects are usually maintained
for 2 to 8 hours.
The majority of a dose of vasopressin is metabolized and rapidly
destroyed in the liver and kidneys.
Vasopressin has a plasma half-life of about 10 to 20 minutes.
Approximately 5% of a subcutaneous
dose of vasopressin is excreted in urine unchanged after 4 hours.
INDICATIONS AND USAGE:
Vasopressin Injection, USP is indicated for prevention and treatment
of postoperative abdominal
distention, in abdominal roentgenography to dispel interfering gas
shadows and in diabe