מדינה: ארצות הברית
שפה: אנגלית
מקור: NLM (National Library of Medicine)
TRIHEXYPHENIDYL HYDROCHLORIDE (UNII: AO61G82577) (TRIHEXYPHENIDYL - UNII:6RC5V8B7PO)
State of Florida DOH Central Pharmacy
TRIHEXYPHENIDYL HYDROCHLORIDE
TRIHEXYPHENIDYL HYDROCHLORIDE 2 mg
ORAL
PRESCRIPTION DRUG
Trihexyphenidyl HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.
Trihexyphenidyl HCl tablets are available as follows: 2 mg – round, flat, scored, white tablets; debossed "5971" above the score and "V" below the score. 5 mg – round, flat, scored, white tablets; debossed "5972" above the score and "V" below the score. They are supplied by State of Florida DOH Central Pharmacy as follows:
Abbreviated New Drug Application
TRIHEXYPHENIDYL HYDROCHLORIDE - TRIHEXYPHENIDYL HYDROCHLORIDE TABLET STATE OF FLORIDA DOH CENTRAL PHARMACY ---------- TRIHEXYPHENIDYL HYDROCHLORIDE TABLETS, USP RX ONLY DESCRIPTION Trihexyphenidyl HCl is a synthetic antispasmodic. Each tablet for oral administration, contains 2 mg or 5 mg trihexyphenidyl HCl, each strength also containing as inactive ingredients: magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. Trihexyphenidyl HCl is a white or slightly off white, crystalline powder, having not more than a very faint odor. Trihexyphenidyl HCl is the substituted piperidine salt, 1-piperidinepropanol,α-cyclohexyl-α-phenyl- ,hydrochloride,(±)-. The structural formula is: CLINICAL PHARMACOLOGY Trihexyphenidyl exerts a direct inhibitory effect upon the parasympathetic nervous system. It also has a relaxing effect on smooth musculature; exerted both directly upon the muscle tissue itself and indirectly through an inhibitory effect upon the parasympathetic nervous system. Its therapeutic properties are similar to those of atropine, although undesirable side effects are ordinarily less frequent and severe than with the latter. INDICATIONS AND USAGE Trihexyphenidyl HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones. WARNINGS Patients to be treated with trihexyphenidyl HCl should have a gonioscope evaluation and close monitoring of intraocular pressures at regular periodic intervals. PRECAUTIONS Although trihexyphenidyl HCl is _not_ contraindicated for patients with cardiac, liver, or kidney disorders, or with hypertension, such patients should be maintained under close observation. Since the use of trihexyphenidyl HCl ma קרא את המסמך השלם