SPIRONOLACTONE tablet

מדינה: ארצות הברית

שפה: אנגלית

מקור: NLM (National Library of Medicine)

מרכיב פעיל:

SPIRONOLACTONE (UNII: 27O7W4T232) (SPIRONOLACTONE - UNII:27O7W4T232)

זמין מ:

St Marys Medical Park Pharmacy

INN (שם בינלאומי):

SPIRONOLACTONE

הרכב:

SPIRONOLACTONE 25 mg

סוג מרשם:

PRESCRIPTION DRUG

מצב אישור:

Abbreviated New Drug Application

מאפייני מוצר

SPIRONOLACTONE- SPIRONOLACTONE TABLET
ST MARYS MEDICAL PARK PHARMACY
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SPIRONOLACTONE TABLETS USP
WARNING
Spironolactone has been shown to be a tumorigen in chronic toxicity
studies in rats (see
_Precautions_). Spironolactone should be used only in those conditions
described under _Indications_
_and Usage_. Unnecessary use of this drug should be avoided.
DESCRIPTION
Spironolactone oral tablets contain 25 mg, 50 mg, or 100 mg of the
aldosterone antagonist
spironolactone,
17-hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid
γ-lactone acetate,
which has the following structural formula:
Spironolactone is practically insoluble in water, soluble in alcohol,
and freely soluble in benzene and in
chloroform.
Spironolactone tablets, 25 mg contain the following inactive
ingredients: anhydrous lactose, colloidal
silicon dioxide, crospovidone, docusate sodium 85%/sodium benzoate
15%, entrapped peppermint
flavor, magnesium stearate, microcrystalline cellulose, and sodium
starch glycolate.
Spironolactone tablets, 50 mg and 100 mg contain the following
inactive ingredients: anhydrous lactose,
carnauba wax, colloidal silicon dioxide, docusate sodium 85%/sodium
benzoate 15%, entrapped
peppermint flavor, hypromellose, magnesium stearate, microcrystalline
cellulose, polydextrose,
polyethylene glycol, povidone, sodium starch glycolate, titanium
dioxide, and triacetin.
ACTIONS / CLINICAL PHARMACOLOGY
MECHANISM OF ACTION
Spironolactone is a specific pharmacologic antagonist of aldosterone,
acting primarily through
competitive binding of receptors at the aldosterone-dependent
sodiumpotassium exchange site in the
distal convoluted renal tubule. Spironolactone causes increased
amounts of sodium and water to be
excreted, while potassium is retained. Spironolactone acts both as a
diuretic and as an antihypertensive
drug by this mechanism. It may be given alone or with other diuretic
agents that act more proximally in
the renal tubule.
ALDOSTERONE ANTAGONIST ACTIVITY
Increased levels of the mineralocorticoid, aldoster