מדינה: ארצות הברית
שפה: אנגלית
מקור: NLM (National Library of Medicine)
GENTAMICIN SULFATE (UNII: 8X7386QRLV) (GENTAMICIN - UNII:T6Z9V48IKG), BETAMETHASONE VALERATE (UNII: 9IFA5XM7R2) (BETAMETHASONE - UNII:9842X06Q6M)
Schuyler LLC
GENTAMICIN SULFATE
GENTAMICIN 0.57 mg in 1 mL
TOPICAL
PRESCRIPTION
INDICATIONS : For the treatment of infected superficial lesions in dogs caused by bacteria sensitive to gentamicin. CONTRAINDICATIONS : If hypersensitivity of any of the components occurs, treatment with this product should be discontinued and appropriate therapy instituted.
HOW SUPPLIED : Plastic spray bottle containing 60 mL, 120 mL and 240 mL of Gentamicin Sulfate with Betamethasone Valerate Topical Spray.
Abbreviated New Animal Drug Application
RELIFOR - GENTAMICIN SULFATE WITH BETAMETHASONE VALERATE SPRAY SCHUYLER LLC ---------- RELIFOR TOPICAL SPRAY ANADA # 200-188, APPROVED BY FDA VETERINARY FOR TOPICAL USE IN DOGS ONLY. CAUTION: FEDERAL LAW RESTRICTS THIS DRUG TO USE BY OR ON THE ORDER OF A LICENSED VETERINARIAN. DESCRIPTION: Each mL contains: gentamicin sulfate equivalent to 0.57 mg gentamicin base, betamethasone valerate equivalent to 0.284 mg betamethasone, 163 mg isopropyl alcohol, propylene glycol, methylparaben and propylparaben as preservatives, purified water q.s. Hydrochloric acid may be added to adjust pH. CHEMISTRY: Gentamicin is a mixture of aminoglycoside antibiotics derived from the fermentation of _Micromonospora purpurea_. Gentamicin sulfate is a mixture of sulfate salts of the antibiotics produced in this fermentation. The salts are weakly acidic and freely soluble in water. Gentamicin sulfate contains not less than 500 micrograms of gentamicin base per milligram. Betamethasone valerate is a synthetic glucocorticoid. PHARMACOLOGY: Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. _In vitro_, gentamicin is bactericidal against a wide variety of gram- positive and gram-negative bacteria isolated from domestic animals. Specifically, gentamicin is active against the following organisms isolated from canine skin: _Alcaligenes_ sp., _Citrobacter_ sp., _Klebsiella_ sp., _Pseudomonas aeruginosa_, indole-positive and negative _Proteus_ sp., _Escherichia coli_, _Enterobacter_ sp., _Staphylococcus_ sp. and _Streptococcus_ sp. Betamethasone valerate emerged from intensive research as the most promising of some 50 newly synthesized corticosteroids in the experimental model described by McKenzie, et al. This human bioassay technique has been found reliable for evaluating the vasoconstrictor properties of new topical corticosteroids and is useful in predicting clinical efficacy. Betamethasone valerate in veterinary medicine has been shown to provide anti-inflammatory and antiprur קרא את המסמך השלם