מדינה: ארצות הברית
שפה: אנגלית
מקור: NLM (National Library of Medicine)
PYRIDOSTIGMINE BROMIDE (UNII: KVI301NA53) (PYRIDOSTIGMINE - UNII:19QM69HH21)
AvPAK
ORAL
PRESCRIPTION DRUG
Pyridostigmine Bromide Tablets are useful in the treatment of myasthenia gravis. Pyridostigmine Bromide Tablets are contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.
Pyridostigmine Bromide Tablets, USP are available containing 60 mg of pyridostigmine bromide supplied in unit dose packaging. NDC 50268-638-15 (10 tablets per card, 5 cards per carton). Each tablet is cross-scored on one side and engraved "OCEANSIDE 302" on the other side. Store Pyridostigmine Bromide Tablets at 25°C (77°F); excursions permitted to 15° - 30°C (59°-86°F). Keep Pyridostigmine Bromide Tablets in a dry place. Dispensed in Unit Dose Package. For Institutional Use Only.
New Drug Application Authorized Generic
PYRIDOSTIGMINE BROMIDE- PYRIDOSTIGMINE BROMIDE TABLET AVPAK ---------- PYRIDOSTIGMINE BROMIDE TABLETS, USP RX ONLY DESCRIPTION Pyridostigmine Bromide Tablets, USP is an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is: Pyridostigmine bromide is available as tablets containing 60 mg pyridostigmine bromide; each tablet also contains lactose, silicon dioxide and stearic acid. CLINICAL PHARMACOLOGY Pyridostigmine bromide inhibits the destruction of acetylcholine by cholinesterase and thereby permits freer transmission of nerve impulses across the neuromuscular junction. Pyridostigmine is an analog of neostigmine (Prostigmin), but differs from it in certain clinically significant respects; for example, pyridostigmine is characterized by a longer duration of action and fewer gastrointestinal side effects. INDICATIONS AND USAGE Pyridostigmine Bromide Tablets are useful in the treatment of myasthenia gravis. CONTRAINDICATIONS Pyridostigmine Bromide Tablets are contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below. WARNINGS Although failure of patients to show clinical improvement may reflect underdosage, it can also be indicative of overdosage. As is true of all cholinergic drugs, overdosage of Pyridostigmine Bromide Tablets may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death. Myasthenic crisis due to an increase in the severity of the disease is also accompanied by extreme muscle weakness, and thus may be difficult to distinguish from cholinergic crisis on a symptomatic basis. Such differentiation is extremely important, since increases in doses of Pyridostigmine Bromide Tablets or other drugs of this c קרא את המסמך השלם