מדינה: מלזיה
שפה: אנגלית
מקור: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
Doxofylline
EURODRUG LABORATORIES (M) SDN. BHD.
Doxofylline
100 Tablets; 20 Tablets
ABC Farmaceutici SPA
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ PUROXAN ® TABLET _Doxofylline 400mg Tablet) _ _ _ 1 WHAT IS IN THIS LEAFLET 1. What PUROXAN Tablet is used for 2. How PUROXAN Tablet works 3. Before you use PUROXAN Tablet 4. How to use PUROXAN Tablet 5. While you are using it 6. Side effects 7. Storage and Disposal of PUROXAN Tablet 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT PUROXAN TABLETIS USED FOR AND HOW IT WORKS - PUROXAN Tablet contains Doxofylline as the active ingredient. - PUROXAN Tablet is indicated for the treatment of bronchial asthma and Chronic Obstructive Pulmonary Disease (COPD) associated with bronchospasm. Doxofylline is a bronchodilator structurally classified as a xanthine derivative. Doxofylline directly relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels, thus acting mainly as a bronchodilator and smooth muscle relaxant. At high concentrations, doxofylline is also able to inhibit the cellular release of histamine BEFORE YOU USE PUROXAN TABLET _ _ _When you must not use it:_ • if you are allergic or hypersensitive to the active substance or any of the other ingredients of PUROXAN Tablet • if you are breast feeding _ _ _ _ _Before you start to use it_ Always tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. _Taking other medicines _ Doxofylline should not be administered together with other xanthine derivatives, including beverages and foods containing excessive amounts of caffeine. Please tell your doctor or pharmacist if you are taking other drugs like erythromycin, troleandomycin, lincomycin and other antibiotics of the same group, allopurinol, cimetidine, propanolol, ephedrine and anti- flu vaccine. In this case you may require lower dose of Doxofylline. Similarly if you are taking phenytoin or other anticonvulsants and if you are smoking you may require higher doses of Doxofylline. HOW TO USE PUROXAN TABLET Al קרא את המסמך השלם
PRESCRIPTION DRUG ONLY INTERNATIONAL NON-PROPRIETARY NAME Doxofylline PRODUCT DESCRIPTION Each tablet contains Doxofylline - 400 mg Description: White, round, scored tablets with smooth surface. THERAPEUTIC PROPERTIES Doxofylline is a bronchodilator structurally classified as a xanthine derivative. Doxofylline directly relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels, thus acting mainly as a bronchodilator and smooth muscle relaxant. PHARMACODYNAMICS Doxofylline is a novel bronchodilator structurally classified as a xanthine derivative. Doxofylline directly relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels, thus acting mainly as a bronchodilator and smooth muscle relaxant. Doxofylline did not antagonise adenosine A1, A2B and A3 receptors; there was only a modest inhibition at the highest tested concentration (10 4 M) against A2A receptors. This may explain the improved tolerability profile of doxofylline in comparison with other xanthine based medicines. Doxofylline does not inhibit any of the PDE enzyme subtypes, except a modest inhibition at the highest tested concentra- tion (10 4 M) against PDE2A1. PDE3 inhibitors are known to cause vasodilation and cardiac effects. The lack of effect of doxofylline on PDEs may help explain its improved tolerability profile on the cardiovascular system. Doxofylline does not exert any significant inhibitory effect against any of the 11 HDAC enzymes. Doxofylline significantly inhibited the migration of neutrophils and the release of IL-6 and TNF-α into the lung lumen, demonstrating the anti-inflammatory action of doxofylline. PHARMACOKINETICS The half-life of Doxofylline is greater than six hours; so as to allow effective constant plasma levels with a t.i.d. dose regimen. Single dose pharmacokinetic studies in man after oral and intravenous administration defined distribution and absorption of the drug. After i.v. administration of 100 mg to 5 healthy volunteers, distribution of Doxofylline in plasma followed a bi-comp קרא את המסמך השלם